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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45444
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dc.creatorJulia Mourão Bragapt_BR
dc.creatorMarcela Carvalho Espaladoript_BR
dc.creatorMaria Elisa de Souza e Silvapt_BR
dc.creatorLuciana Carla Brito Nevespt_BR
dc.creatorLeda Quercia Vieirapt_BR
dc.creatorAntônio Paulino Ribeiro Sobrinhopt_BR
dc.date.accessioned2022-09-24T17:24:41Z-
dc.date.available2022-09-24T17:24:41Z-
dc.date.issued2018-08-08-
dc.citation.volume52pt_BR
dc.citation.issue2pt_BR
dc.citation.spage149pt_BR
dc.citation.epage157pt_BR
dc.identifier.doihttps://doi.org/10.1111/iej.12992pt_BR
dc.identifier.issn01432885pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45444-
dc.description.resumoAim To evaluate the mRNA expression levels of the cytokines interferon-γ, tumour necrosis factor-α, interleukin (IL)-1β, IL-10, IL-6, VEGF, and AGT and the chemokine CCL2/MCP-1 in periapical interstitial fluid associated with root canal infections before and after the reduction of the bacterial load using a cleaning procedure. Methodology The case group included 11 patients with chronic liver disease, and the control group included 11 healthy patients. Clinical samples were taken from teeth with pulp necrosis. After cleaning and drying the canal, three paper points were introduced into the root canal and passed through the root apex (2 mm) into the periapical tissues for 1 min. The samples were collected immediately after root canal cleaning and 7 days later to characterize those gene expression levels using real-time PCR. The data were subjected to the Shapiro–Wilk and the Wilcoxon tests. Results In the control group, significantly increased expression of the pro-inflammatory cytokines IFN-γ and TNF-α was observed in teeth with restrained bacterial loads (day 7) (P < 0.05). Similarly, increased TNF-α expression was found on day 7 in the liver group (P < 0.05). No differences were observed in the expression levels of the IL-1β, IL-10 and, IL-6, MCP-1/CCL-2 and VEGF between the first collection (day 0) and second collection (day 7), over time in either group. Conclusion Chronic liver disease patients exhibited sufficient immunologic ability showing relatively similar expression levels of cytokines, chemokines and angiogenic factors in periapical samples compared with the responses from no-chronic liver disease patients. The outcomes of this study suggest that liver impairment did not compromise the periapical immune responsept_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Endodontic Journalpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAngiogenic factorspt_BR
dc.subjectCytokinespt_BR
dc.subjectEndodonticspt_BR
dc.subjectLiver transplantpt_BR
dc.subjectPeriapical diseasept_BR
dc.subject.otherRNA messengerpt_BR
dc.subject.otherCytokinespt_BR
dc.subject.otherInfectionspt_BR
dc.subject.otherDental pulp cavitypt_BR
dc.titleImmunological profile of teeth with inflammatory periapical disease from chronic liver disease patientspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.12992pt_BR
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