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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45466
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dc.creatorLuciano Tavares Angelo Cintrapt_BR
dc.creatorFrancine Benettipt_BR
dc.creatorÍndia Olinta de Azevedo Queirozpt_BR
dc.creatorLuciana Louzada Ferreirapt_BR
dc.creatorLoiane Massunaript_BR
dc.creatorCarlos Roberto Emerenciano Buenopt_BR
dc.creatorSandra Helena Penha de Oliveirapt_BR
dc.creatorGomes-Filhopt_BR
dc.date.accessioned2022-09-24T19:18:01Z-
dc.date.available2022-09-24T19:18:01Z-
dc.date.issued2017-12-
dc.citation.volume43pt_BR
dc.citation.issue12pt_BR
dc.citation.spage2088pt_BR
dc.citation.epage2092pt_BR
dc.identifier.doi10.1016/j.joen.2017.07.016pt_BR
dc.identifier.issn00992399pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45466-
dc.description.resumoIntroduction: Many endodontic sealers are available, but the search for the ideal sealer continues. This study evaluated the cytotoxicity and biocompatibility of Sealer Plus, a new resin epoxy–based endodontic sealer con- taining calcium hydroxide. AH Plus, Endofill, and Simpli- Seal endodontics sealers were used for comparison. Methods: L929 fibroblasts were cultured, and an MTT assay was used to determine the cytotoxicity of the sealer extracts at 6, 24, 48, and 72 hours. Tubes contain- ing materials or empty tubes for control were inserted into the subcutaneous tissues of 20 rats. After 7 and 30 days, the rats were killed, and the tubes were removed with the surrounding tissues for histologic analysis. The data were submitted to statistical tests (P < .05). Results: Undiluted Sealer Plus exhibited less cytotoxicity compared with other undiluted extracts at 6 hours (P < .05), and cell viability was higher for all Sealer Plus extracts after 24 hours (P < .05). At 48 hours, the undiluted and ½ Sealer Plus dilution were the ex- tracts with less cytotoxicity (P < .05). At 72 hours, cell viability was higher for the undiluted and ½ Sealer Plus dilution compared with the other sealers (P < .05). At 7 days, Endofill and SimpliSeal had higher inflammation compared with the control and Sealer Plus (P < .05); AH Plus had moderate inflammation (P > .05). At 30 days, control, Sealer Plus, and AH Plus had less inflammation (P < .05). The fibrous capsule was thick at 7 days and thin at 30 days, except for SimpliSeal. Conclusions: In general, Sealer Plus promoted greater cell viability and was more biocompatible compared with the other sealers.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Endodonticspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBiocompatibilitypt_BR
dc.subjectCalcium hydroxidept_BR
dc.subjectCytotoxicitypt_BR
dc.subjectEndodontic sealerspt_BR
dc.subjectResin epoxypt_BR
dc.subject.otherMaterials testingpt_BR
dc.subject.otherCalcium hydroxidept_BR
dc.subject.otherEpoxy resinspt_BR
dc.subject.otherNoxaept_BR
dc.titleEvaluation of the cytotoxicity and biocompatibility of new resin epoxy-based endodontic sealer containing calcium hydroxidept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0099239917309056?via%3Dihubpt_BR
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