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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45470
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dc.creatorLuciano Tavares Angelo Cintrapt_BR
dc.creatorFrancine Benettipt_BR
dc.creatorÍndia Olinta de Azevedo Queirozpt_BR
dc.creatorJuliana Maria de Araújo Lopespt_BR
dc.creatorSandra Helena Penha de Oliveirapt_BR
dc.creatorGustavo Sivieri Araújopt_BR
dc.creatorJoão Eduardo Gomes-Filhopt_BR
dc.date.accessioned2022-09-24T19:36:26Z-
dc.date.available2022-09-24T19:36:26Z-
dc.date.issued2017-05-
dc.citation.volume43pt_BR
dc.citation.issue5pt_BR
dc.citation.spage774pt_BR
dc.citation.epage778pt_BR
dc.identifier.doi10.1016/j.joen.2016.12.018pt_BR
dc.identifier.issn00992399pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45470-
dc.description.resumoIntroduction: Mineral trioxide aggregate (MTA) has excellent biological properties, but its handling proper- ties have been criticized for both ProRoot MTA (Tulsa Dental Products, Tulsa, OK) and white MTA-Angelus (MTA-Ang; Angelus Ind ustria de Produtos Odon- tol ogicos S/A, Londrina, PR, Brazil). Angelus MTA HP (high plasticity) (Angelus Ind ustria de Produtos Odon- tol ogicos S/A) has been introduced recently. Considering the importance of biological properties of materials that will be in contact with the tissues, this study evaluated the cytotoxicity, biocompatibility, and biomineralization of MTA HP compared with white MTA-Ang. Methods: L929 fibroblast cell lines were cultured, and cell viability was assessed at 6, 24, 48, and 72 hours using the ala- mar Blue assay (Thermo Fisher Scientific, Waltham, MA). A subcutaneous implant test was performed with polyethylene tubes containing 1 of the materials or empty tubes (control) using 20 Wistar rats. After 7 and 30 days of implantation, the tubes with surrounding tis- sues were removed for analysis using hematoxylin-eosin or von Kossa stain or they remained unstained for obser- vation under polarized light. The results were statisti- cally analyzed (P < .05). Results: A significant increase in cell viability for MTA HP was observed after 24, 48, and 72 hours compared with the control (P < .05). At 72 hours, MTA HP exhibited a higher viability compared with white MTA-Ang (P < .05). His- tologic analysis performed at 7 days showed moderate inflammation and a thick fibrous capsule in all groups (P > .05). At 30 days, mild inflammation and a thin fibrous capsule were observed in all groups (P > .05). All materials had structures positive for von Kossa and birefringent to polarized light. Conclusions: MTA HP showed biocompatibility and biomineralization similar to MTA-Ang. In addition, MTA HP showed increased fibroblast cell viability compared with white MTA-Ang after a longer periodpt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Endodonticspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBiocompatibilitypt_BR
dc.subjectBiomineralization abilitypt_BR
dc.subjectCytotoxicitypt_BR
dc.subjectMineral trioxide aggregatept_BR
dc.subject.otherMaterials testingpt_BR
dc.subject.otherBiomineralizationpt_BR
dc.titleCytotoxicity, biocompatibility, and biomineralization of the new high-plasticity mta materialpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0099239916310640?via%3Dihubpt_BR
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