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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/45487
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dc.creatorLuciana Lousada Ferreirapt_BR
dc.creatorJoão Eduardo Gomes-Filhopt_BR
dc.creatorFrancine Benettipt_BR
dc.creatorMarina Carminattipt_BR
dc.creatorEdilson Ervolinopt_BR
dc.creatorAndré Luiz Fraga Brisopt_BR
dc.creatorLuciano Tavarez Angelo Cintrapt_BR
dc.date.accessioned2022-09-24T20:40:07Z-
dc.date.available2022-09-24T20:40:07Z-
dc.date.issued2017-08-30-
dc.citation.volume51pt_BR
dc.citation.issue03pt_BR
dc.citation.spage347pt_BR
dc.citation.epage356pt_BR
dc.identifier.doi10.1111/iej.12852pt_BR
dc.identifier.issn01432885pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/45487-
dc.description.resumoAim To evaluate the influence of tooth bleaching on immunoregulatory cytokines production (IL-6, Tumour necrosis factor (TNF)-α and IL-17) in the pulp tissue of normoglycaemic and diabetic rats. Methodology Twenty-eight rats were divided into normoglycaemic and diabetic rats (n = 14). Diabetes mellitus (DM) was induced with a single dose of alloxan diluted in citrate buffer via intramuscular injection. After DM confirmation, all rats were sedated and tooth bleaching was performed using 35% hydrogen peroxide on the right maxillary molars for 30 min. Left molars were used as controls. Bleaching resulted in four hemimaxillae groups: normoglycaemic (N), N-bleached (NBle), diabetic (D) and D-bleached (DBle). After 2 and 30 days, rats were euthanized and hemimaxillae processed for analysis by haematoxylin and eosin and immunohistochemistry. Results within and between animals were submitted to Wilcoxon signed-rank and Mann–Whitney tests (P < 0.05). Results At 2 days, the NBle group had mild, and the DBle had severe inflammatory infiltration in the pulpal tissue (P < 0.05). TNF-α and IL-6 cytokines were associated with increased immunolabelling in the bleached groups compared to nonbleached (P < 0.05). However, IL-17 had increased immunolabelling in the NBle compared to the N and DBle group (P < 0.05). At 30 days, reactionary dentine was observed in the coronal pulp of all bleached teeth and no inflammation was present (P > 0.05). TNF-α cytokines had increased immunolabelling in the DBle group compared to the D group (P < 0.05). However, for IL-6 and IL-17, no difference was observed in this period (P > 0.05). Conclusions Tooth bleaching increased IL-6 and TNF-α in the pulp tissue regardless of diabetes mellitus; however, diabetic rats had higher TNF-α levels for longer periods. Tooth bleaching influenced the increase in IL-17 in the early periods in normoglycaemic ratspt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulopt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Endodontic Journalpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectDental bleachingpt_BR
dc.subjectDiabetes Mellituspt_BR
dc.subjectInflammatory responsept_BR
dc.subjectProinflammatory cytokinespt_BR
dc.subject.otherTooth bleachingpt_BR
dc.subject.otherDiabetes Mellituspt_BR
dc.subject.otherTumor necrosis factorspt_BR
dc.subject.otherCytokinespt_BR
dc.titleThe effect of dental bleaching on pulpal tissue response in a diabetic animal model: a study of immunoregulatory cytokinespt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/iej.12852pt_BR
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