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http://hdl.handle.net/1843/45900| Type: | Artigo de Periódico |
| Title: | Anti-inflammatory potential of a carvedilol gel in the pulpal tissue of rats after dental bleaching: a histopathological evaluation |
| Authors: | Lidiane Mendes Louzada André Luiz Fraga Briso Francine Benetti Letícia Vieira Rogério de Castilho Jacinto Elói Dezan-Júnior Luciano Tavares Ângelo Cintra |
| Abstract: | Aim: Carvedilol is an antioxidant that decreases inflammation in periodontitis. The hydrogen peroxide (H2 O2 ) of bleaching gel causes inflammation and necrosis of the dental pulp. In the present study, we evaluated the anti-inflammatory potential of carvedilol in the pulp of rats after bleaching. Methods: The right upper molars of rats received 35% H2 O2 (1× 30 minutes), and the left upper molars were used as the control. Half of the rats received carvedilol gel (1× 10 minutes), forming the following groups: bleached, bleached followed by carvedilol (bleached+carvedilol), and control. After 2 and 30 days (N = 7 hemi-maxillae/group), the rats were killed for histological evaluation, and statistical tests were performed (P < 0.05). Results: After 2 days, the bleached group showed necrosis in the occlusal third of the coronal pulp, and in the bleached+carvedilol group, severe inflammation (P > 0.05), both different from the control (P < 0.05). In the middle third, the bleached group showed severe inflammation, and the bleached+carvedilol group showed moderate inflammation (P > 0.05), with the only difference between the bleached and control groups (P < 0.05). In the cervical third, the bleached group showed moderate inflammation, and the bleached+carvedilol group showed mild inflammation (P > 0.05). The difference again was only between the bleached and control groups (P < 0.05). At 30 days, there was no inflammation and a marked amount of tertiary dentin in bleached teeth (P > 0.05). Conclusion: Carvedilol gel has the potential of minimizing H2 O2 damage, especially in deep regions of the dental pulp of rats after bleaching. |
| Subject: | Carvedilol Hydrogen peroxide Inflammation Dental pulp cavity Tooth bleaching |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1111/jicd.12401 |
| URI: | http://hdl.handle.net/1843/45900 |
| Issue Date: | 28-Jan-2019 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/jicd.12401 |
| metadata.dc.relation.ispartof: | Journal of Investigative and Clinical Dentistry |
| Appears in Collections: | Artigo de Periódico |
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