Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/46929
Type: Artigo de Periódico
Title: Central cholinergic activation induces greater thermoregulatory and cardiovascular responses in spontaneously hypertensive than in normotensive rats
Authors: Sueli Ferreira da Fonseca
Vanessa Amaral Mendonça
Sara Barros Silva
Talita Emanuela Domingues
Dirceu Sousa Melo
Jeanne Brenda Martins
Washington Pires
Cynthia Ferreira Fernandes Santos
Wagner de Fátima Pereira
Laura Hora Rios Leite
Cândido Celso Coimbra
Hércules Ribeiro Leite
Ana Cristina Rodrigues Lacerda
Abstract: There is evidence that central cholinergic stimulation increases heat dissipation in normotensive rats besides causing changes on the cardiovascular system via modulation of baroreceptors activity. However, the contribution of the central cholinergic system on thermoregulatory responses and its relationship with cardiovascular adjustments in spontaneously hypertensive rats (SHRs), an animal model of reduced baroreceptor sensitivity and thermoregulatory deficit, has not been completely clarified. Therefore, the aim of this study was to verify the involvement of the central cholinergic system in cardiovascular and thermoregulatory adjustments in SHRs. Male Wistar rats (n = 17) and SHRs (n = 17) were implanted with an intracerebroventricular cannula for injections of 2 µL of physostigmine (phy) or saline solution. Tail temperature (Ttail), internal body temperature (Tint), systolic arterial pressure (SAP), heart rate (HR) and metabolic rate were registered during 60 min while the animals remained at rest after randomly receiving the injections. The variability of the SAP and the HR was estimated by the fast Fourier transform. Phy treatment began a succession of cardiovascular and thermoregulatory responses that resulted in increased SAP, reduced HR and increased Ttail in both Wistar and SHRs groups. The magnitude of these effects seems to be more intense in SHRs, since the improvement of heat dissipation reflected in Tint. Taken together, these results provide evidence that hypertensive rats present greater cardiovascular and thermoregulatory responses than normotensive rats after central cholinergic stimulation.
Subject: Corpo - Temperatura - Regulação
Fisostigmina
Hipertensão
Sinapses
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: EEF - DEPARTAMENTO DE FISIOTERAPIA
ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
Rights: Acesso Restrito
metadata.dc.identifier.doi: https://doi.org/10.1016/j.jtherbio.2018.08.014
URI: http://hdl.handle.net/1843/46929
Issue Date: Oct-2018
metadata.dc.url.externa: https://www.sciencedirect.com/science/article/pii/S0306456518300986?via%3Dihub#!
metadata.dc.relation.ispartof: Journal of Thermal Biology
Appears in Collections:Artigo de Periódico

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