Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/46929| Type: | Artigo de Periódico |
| Title: | Central cholinergic activation induces greater thermoregulatory and cardiovascular responses in spontaneously hypertensive than in normotensive rats |
| Authors: | Sueli Ferreira da Fonseca Vanessa Amaral Mendonça Sara Barros Silva Talita Emanuela Domingues Dirceu Sousa Melo Jeanne Brenda Martins Washington Pires Cynthia Ferreira Fernandes Santos Wagner de Fátima Pereira Laura Hora Rios Leite Cândido Celso Coimbra Hércules Ribeiro Leite Ana Cristina Rodrigues Lacerda |
| Abstract: | There is evidence that central cholinergic stimulation increases heat dissipation in normotensive rats besides causing changes on the cardiovascular system via modulation of baroreceptors activity. However, the contribution of the central cholinergic system on thermoregulatory responses and its relationship with cardiovascular adjustments in spontaneously hypertensive rats (SHRs), an animal model of reduced baroreceptor sensitivity and thermoregulatory deficit, has not been completely clarified. Therefore, the aim of this study was to verify the involvement of the central cholinergic system in cardiovascular and thermoregulatory adjustments in SHRs. Male Wistar rats (n = 17) and SHRs (n = 17) were implanted with an intracerebroventricular cannula for injections of 2 µL of physostigmine (phy) or saline solution. Tail temperature (Ttail), internal body temperature (Tint), systolic arterial pressure (SAP), heart rate (HR) and metabolic rate were registered during 60 min while the animals remained at rest after randomly receiving the injections. The variability of the SAP and the HR was estimated by the fast Fourier transform. Phy treatment began a succession of cardiovascular and thermoregulatory responses that resulted in increased SAP, reduced HR and increased Ttail in both Wistar and SHRs groups. The magnitude of these effects seems to be more intense in SHRs, since the improvement of heat dissipation reflected in Tint. Taken together, these results provide evidence that hypertensive rats present greater cardiovascular and thermoregulatory responses than normotensive rats after central cholinergic stimulation. |
| Subject: | Corpo - Temperatura - Regulação Fisostigmina Hipertensão Sinapses |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | EEF - DEPARTAMENTO DE FISIOTERAPIA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jtherbio.2018.08.014 |
| URI: | http://hdl.handle.net/1843/46929 |
| Issue Date: | Oct-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0306456518300986?via%3Dihub#! |
| metadata.dc.relation.ispartof: | Journal of Thermal Biology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.