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Type:	Artigo de Periódico
Title:	Influence of pain-relieving therapies on inflammation and the expression of proinflammatory neuropeptides after dental bleaching treatment
Authors:	Livia Maria Alves Valentim da Silva Luciano Tavares Angelo Cintra Marjorie Oliveira Gallinari Francine Benetti Vanessa Rahal Edilson Ervolino Sibele Alcantara André Luiz Fraga Briso
Abstract:	Objectives To minimize the tooth sensitivity caused by in-office bleaching, many dentists use non-steroidal anti-inflammatory drugs and topical desensitizing gels containing potassium nitrate and sodium fluoride. This study aimed to evaluate the influence of these substances on inflammation and the expression of substance P and calcitonin gene-related peptide in pulp nerve fibers. Materials and Methods Seventy-two rats were divided into 6 groups as follows: GI, control; GII, only dental bleaching; GIII, only ibuprofen; GIV, ibuprofen administered 30 minutes before and after the bleaching treatment and every 12 hours until the analysis; GV, only topical application of a desensitizing agent; and GVI, topical application of a desensitizing agent before dental bleaching. Placebo gel was applied to the upper left jaw and the bleaching agent was applied to the upper right jaw in all groups. Subsequently, the groups were divided into 3 subgroups based on the time of analysis: 0, 24, and 48 hours after bleaching (n = 8). The rats were euthanized and the maxillae were processed and evaluated by histopathological and immunohistochemical analyses. The data were analyzed using the Kruskal-Wallis test, followed by the Dunn test (p < 0.05). Results In the bleaching groups, the inflammatory process and expression of neuropeptides decreased over time. The animals in which a desensitizing agent was applied showed better results within 24 hours. Conclusions The use of a desensitizing agent had positive effects on inflammation and pain-related neuropeptide expression, minimizing the painful effects of dental bleaching treatment
Subject:	Tooth bleaching Hydrogen peroxide Ibuprofen Research Pain Reactive oxygen species
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.5395/rde.2020.45.e20
URI:	http://hdl.handle.net/1843/47208
Issue Date:	28-Feb-2020
metadata.dc.url.externa:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239683/
metadata.dc.relation.ispartof:	Restorative Dentistry & Endodontics
Appears in Collections:	Artigo de Periódico

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