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http://hdl.handle.net/1843/48831| Tipo: | Artigo de Periódico |
| Título: | The angiotensin converting enzyme 2 (ACE2), gut microbiota, and cardiovascular health |
| Autor(es): | Joao Marcus Oliveira Andrade Deborah de Farias Lelis Valeria Mafra Cota Júnio Cota Silva |
| Resumo: | Background: The renin-angiotensin system (RAS) is an important enzymatic system responsible for the regulation of biological functions, such as the arterial pressure, hydroelectrolytic control, vascular vasodilatation/vasoconstriction and more recently metabolic functions. Objectives: The aim of the present review is to discuss the associations between the gut microbiome and the renin-angiotensin system and the influence of their intimate relationship on the cardiovascular health. Methods: A literature review of the main studies published regarding the relationship among the renin-angiotensin system, gut microbiota and cardiovascular health was performed. Results: The association between the ACE2 and gut microbiota has been discussed. It is shown that the ACE2/Ang 1-7 axis modulates the immune response, influencing the microbiota composition, and thus being one of the causes for some diseases physiophatologies, such as diarrhea and intestinal inflammatory disease. Conclusion: The association between RAS and gut microbiota seems to have a strong influence on the genesis of cardiovascular diseases, through direct mechanisms, such as nerve stimulation, or indirectly on metabolic parameters, such as weight, adiposity and lipid profile. |
| Assunto: | Enzima conversora da angiotensina Sistema cardiovascular |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Tipo de Acesso: | Acesso Restrito |
| URI: | http://hdl.handle.net/1843/48831 |
| Data do documento: | 2017 |
| metadata.dc.url.externa: | http://www.eurekaselect.com/article/85062 |
| metadata.dc.relation.ispartof: | Protein & Peptide Letters |
| Aparece nas coleções: | Artigo de Periódico |
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