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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/48831
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dc.creatorJoao Marcus Oliveira Andradept_BR
dc.creatorDeborah de Farias Lelispt_BR
dc.creatorValeria Mafra Cotapt_BR
dc.creatorJúnio Cota Silvapt_BR
dc.date.accessioned2023-01-10T18:32:57Z-
dc.date.available2023-01-10T18:32:57Z-
dc.date.issued2017-
dc.citation.volume24pt_BR
dc.citation.issue9pt_BR
dc.citation.spage827pt_BR
dc.citation.epage832pt_BR
dc.identifier.issn1875-5305pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/48831-
dc.description.resumoBackground: The renin-angiotensin system (RAS) is an important enzymatic system responsible for the regulation of biological functions, such as the arterial pressure, hydroelectrolytic control, vascular vasodilatation/vasoconstriction and more recently metabolic functions. Objectives: The aim of the present review is to discuss the associations between the gut microbiome and the renin-angiotensin system and the influence of their intimate relationship on the cardiovascular health. Methods: A literature review of the main studies published regarding the relationship among the renin-angiotensin system, gut microbiota and cardiovascular health was performed. Results: The association between the ACE2 and gut microbiota has been discussed. It is shown that the ACE2/Ang 1-7 axis modulates the immune response, influencing the microbiota composition, and thus being one of the causes for some diseases physiophatologies, such as diarrhea and intestinal inflammatory disease. Conclusion: The association between RAS and gut microbiota seems to have a strong influence on the genesis of cardiovascular diseases, through direct mechanisms, such as nerve stimulation, or indirectly on metabolic parameters, such as weight, adiposity and lipid profile.pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofProtein & Peptide Letterspt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectRenin-angiotensin systempt_BR
dc.subjectAngiotensin converting enzyme 2pt_BR
dc.subjectGut microbiotapt_BR
dc.subjectCardiovascular healthpt_BR
dc.subject.otherEnzima conversora da angiotensina pt_BR
dc.subject.otherSistema cardiovascular pt_BR
dc.titleThe angiotensin converting enzyme 2 (ACE2), gut microbiota, and cardiovascular healthpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttp://www.eurekaselect.com/article/85062pt_BR
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