1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/48867
Full metadata record
DC FieldValueLanguage
dc.creatorJosé Messias Gomespt_BR
dc.creatorTatiana Fernandes Araujo Almeidapt_BR
dc.creatorTarcília Aparecida da Silvapt_BR
dc.creatorZenilda de Lourdes Cardealpt_BR
dc.creatorHelvécio Costa Menezespt_BR
dc.date.accessioned2023-01-11T19:05:37Z-
dc.date.available2023-01-11T19:05:37Z-
dc.date.issued2020-
dc.citation.volume412pt_BR
dc.citation.issue28pt_BR
dc.citation.spage7799pt_BR
dc.citation.epage7810pt_BR
dc.identifier.doihttps://doi.org/10.1007/s00216-020-02908-xpt_BR
dc.identifier.issn1618-2642pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/48867-
dc.description.resumoBisphenol A and phthalates are endocrine disruptors widely used as chemical additives mainly in plastic products, including materials for dentistry procedures. Besides, many plasticizers have been associated with important diseases requiring performed methods for their quantification. In the present study, an alternative method for the determination of bisphenol A (BPA) and phthalate metabolites in saliva was developed and validated using hollow fiber liquid phase microextraction (HF-LPME) for sample preparation and gas chromatography coupled to ion trap mass spectrometry (GC/MS) for analysis. A mixture of octanol and ethyl octanoate (1:1 v/v) was used as an acceptor phase in hollow fiber to extract the analytes from saliva samples. A Doehlert design was performed to optimize the variable sample agitation and extraction time. The HF-LPME-GC/MS method developed for saliva analysis showed good selectivity, linearity (R2 > 0.900), and precision (CV = 0.86–18.68%). Limits of detection and quantification ranged from 0.03 to 0.53 μg L−¹ and 0.09 to 1.78 μg L−¹, respectively. A high concentration of BPA in the oral cavity and oropharyngeal space is a warning of the possible association with the main cancer of the mouth. The method developed and validated was applied to patients with oral squamous cell carcinoma (study group, n = 16) and patients who did not present any oral lesion (control group, n = 16). A principal component analysis was performed and showed a tendency for the association between oral squamous cell carcinoma (OSCC) and plasticizers.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.departmentFAO - FACULDADE DE ODONTOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAnalytical and Bioanalytical Chemistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBiomonitoramento de salivapt_BR
dc.subjectMétodo LPME-GC / MSpt_BR
dc.subjectExposição odontológica a plastificantespt_BR
dc.subjectEfeitos do bisfenol Apt_BR
dc.subjectMicroextração em fase líquidapt_BR
dc.subjectPatologia Bucalpt_BR
dc.subjectGas chromatographypt_BR
dc.subjectLiquid phase microextractionpt_BR
dc.subjectSalivapt_BR
dc.subjectPhthalatept_BR
dc.subjectBisphenol Apt_BR
dc.subjectBiomonitoringpt_BR
dc.subject.otherQuímica analíticapt_BR
dc.subject.otherExtração (Química)pt_BR
dc.subject.otherCromatografia de gáspt_BR
dc.subject.otherEspectrometria de massapt_BR
dc.subject.otherSalivapt_BR
dc.subject.otherPreparação de amostra (Química)pt_BR
dc.subject.otherTratamento dentáriopt_BR
dc.titleSaliva biomonitoring using LPME-GC/MS method to assess dentistry exposure to plasticizerspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s00216-020-02908-xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1383-6299pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5759-612Xpt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.