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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/50361
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dc.creatorDaniel Barbosa Coelhopt_BR
dc.creatorEduardo Mendonça Pimentapt_BR
dc.creatorIzinara Cruz Rossept_BR
dc.creatorChristiano Venerosopt_BR
dc.creatorGuilherme de Azambuja Pussieldipt_BR
dc.creatorLenice Kappes Beckerpt_BR
dc.creatorEmerson Cruz de Oiveirapt_BR
dc.creatorMaria Raquel Santos Carvalhopt_BR
dc.creatorEmerson Silami Garciapt_BR
dc.date.accessioned2023-02-24T14:10:57Z-
dc.date.available2023-02-24T14:10:57Z-
dc.date.issued2019-10-
dc.citation.volume33pt_BR
dc.citation.issue10pt_BR
dc.citation.spage2655pt_BR
dc.citation.epage2664pt_BR
dc.identifier.doihttps://doi.org/10.1519/JSC.0000000000002575pt_BR
dc.identifier.issn1533-4287pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/50361-
dc.description.resumoCoelho, DB, Pimenta, EM, Rosse, IC, Veneroso, C, Pussieldi, GDA, Becker, LK, De Oliveira, EC, Carvalho, MRS, and Silami-Garcia, E. Alpha-actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer game. J Strength Cond Res 33(10): 2655–2664, 2019—The purpose of this study was to evaluate indicators of muscle damage and hormonal responses after soccer matches and its relation to alpha-actinin-3 (ACTN3) gene expression (XX vs. RR/RX), considering that the R allele produces alpha-actinin-3 and provides greater muscle strength and power. Thirty players (10 XX and 20 RR/RX) younger than 16 years were evaluated in this study. Blood samples were collected immediately before, after, 2, and 4 hours after the games to assess muscle damage (creatine kinase [CK] and alpha-actin) and hormonal responses (interleukin-6 [IL-6], cortisol, and testosterone). Postgame CK was higher as compared to the pregame values in both groups and it was also higher in the RR/RX (p < 0.05) than in the XX. The concentrations of alpha-actin and IL-6 were similar for both groups and did not change over time. Testosterone was increased after the game only in the RR/RX group (p < 0.05). Cortisol concentrations in group RR/RX were higher immediately after the game than before the game, and 2 and 4 hours after the game the concentration decreased (p < 0.05). The RR and RX individuals presented higher markers of muscle microtrauma and hormonal stress, probably because they performed more speed and power actions during the game, which is a self-regulated activity. From the different responses presented by RR/RX and XX genotypes, we conclude that the genotypic profile should be taken into account when planning training workloads and recovery of athlete.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentEEF - DEPARTAMENTO DE ESPORTESpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Strength and Conditioning Researchpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectACTN3pt_BR
dc.subjectPhysiological stresspt_BR
dc.subjectPerformancept_BR
dc.subjectAlpha-actinpt_BR
dc.subjectMuscle microtraumapt_BR
dc.subjectBlood markerspt_BR
dc.subject.otherGenética - Expressãopt_BR
dc.subject.otherEstresse fisiológicopt_BR
dc.subject.otherAvaliação de desempenhopt_BR
dc.subject.otherProteína de ligaçãopt_BR
dc.subject.otherFerimentos e lesõespt_BR
dc.subject.otherMarcadores biológicos / sanguept_BR
dc.titleAlpha-Actinin-3 R577X polymorphism influences muscle damage and hormonal responses after a soccer gamept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://journals.lww.com/nsca-jscr/Fulltext/2019/10000/Alpha_Actinin_3_R577X_Polymorphism_Influences.10.aspxpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0346-492Xpt_BR
dc.identifier.orcidhttp://orcid.org/0000-0001-8968-0089pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2058-689Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8291-3270pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0275-5226pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-9462-5719pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-8982-4705pt_BR
dc.identifier.orcidhttp://orcid.org/0000-0002-1744-448Xpt_BR
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