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Type:	Artigo de Periódico
Title:	Prognostic factors associated with death from visceral leishmaniasis: a case-control study in Brazil
Authors:	Maria Helena Franco Morais Stefanne Aparecida Gonçalves Helen Maria de Oliveira Ramos Lopes Frederico Figueiredo Amâncio Thais Almeida Marques da Silva Carlos Maurício Figueiredo Antunes Fernanda do Carmo Magalhães Mariângela Carneiro
Abstract:	Background: The aim of this study was to identify the prognostic factors associated with death from visceral leishmaniasis (VL) considering the clinical evolution of patients through a case-control study. Methods: We randomly selected 180 cases (death caused by VL) and 180 controls (cured) from Belo Horizonte's hospitals in Brazil, according to data found in the patients' medical records. Five models of multivariate logistic regression were performed following the chronological order of the variables between the onset of the symptoms and evolution of the VL cases. Results: Considering the multivariate models and the stages of clinical evolution of VL, the prognostic factors associated with death are: age >60 y, minor hemorrhagic phenomena, increased abdominal volume, jaundice, dyspnea, malnutrition, TB, billirubin >2 mg/dL, Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) >100 U/L, leukocytes >7000/mm3, hemoglobin <7 g/dL, platelets <50 000/mm3 and infection without defined focus and bleeding. Conclusions: Knowledge regarding the prognostic factors associated with death from VL in different stages of the disease in large Brazilian urban centers such as Belo Horizonte may help optimize patient management strategies and contribute to reduce the high fatality rates in these cities.
Subject:	Estudos de Casos e Controles Leishmaniose Visceral Prognóstico
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - DEPARTAMENTO DE PARASITOLOGIA
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1093/trstmh/traa010
URI:	http://hdl.handle.net/1843/50726
Issue Date:	29-Feb-2020
metadata.dc.url.externa:	https://academic.oup.com/trstmh/article/114/5/346/5766439
metadata.dc.relation.ispartof:	Transactions of the Royal Society of Tropical Medicine and Hygiene
Appears in Collections:	Artigo de Periódico

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