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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51102
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dc.creatorEduardo Burgarelli Lagespt_BR
dc.creatorRenata Salgado Fernandespt_BR
dc.creatorJuliana de Oliveira Silvapt_BR
dc.creatorÂngelo Malachias de Souzapt_BR
dc.creatorGeovanni Dantas Cassalipt_BR
dc.creatorAndré Luís Branco de Barrospt_BR
dc.creatorLucas Antônio Miranda Ferreirapt_BR
dc.date.accessioned2023-03-21T18:51:46Z-
dc.date.available2023-03-21T18:51:46Z-
dc.date.issued2020-
dc.citation.volume132pt_BR
dc.citation.spage1pt_BR
dc.citation.epage12pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2020.110876pt_BR
dc.identifier.issn1950-6007pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51102-
dc.description.resumoDoxorubicin (DOX) is widely used in cancer treatment, however, its use is often limited due to its side effects. To avoid these shortcomings, the encapsulation of DOX into nanocarriers has been suggested. Herein, we proposed a novel nanostructured lipid carrier (NLC) formulation loading DOX, docosahexaenoic acid (DHA), and α-tocopherol succinate (TS) for cancer treatment. DHA is an omega-3 fatty acid and TS is a vitamin E derivative. It has been proposed that these compounds can enhance the antitumor activity of chemotherapeutics. Thus, we hypothesized that the combination of DOX, DHA, and TS in NLC (NLC-DHA-DOX-TS) could increase antitumor efficacy and also reduce toxicity. NLC-DHA-DOX-TS was prepared using emulsification-ultrasound. DOX was incorporated after preparing the NLC, which prevented its degradation during manufacture. High DOX encapsulation efficiency was obtained due to the ion-pairing with TS. This ion-pairing increases lipophilicity of DOX and reduces its crystallinity, contributing to its encapsulation in the lipid matrix. Controlled DOX release from the NLC was observed in vitro, with increased drug release at the acidic environment. In vitro cell studies indicated that DOX, DHA, and TS have synergistic effects against 4T1 tumor cells. The in vivo study showed that NLC-DHA-DOX-TS exhibited the greatest antitumor efficacy by reducing tumor growth in 4T1 tumor-bearing mice. In addition, this formulation reduced mice mortality, prevented lung metastasis, and decreased DOX-induced toxicity to the heart and liver, which was demonstrated by hematologic, biochemical, and histologic analyses. These results indicate that NLC-DHA-DOX-TS may be a promising carrier for breast cancer treatment.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBiomedicine & Pharmacotherapy-
dc.rightsAcesso Restritopt_BR
dc.subjectDoxorubicinpt_BR
dc.subjectCombination therapypt_BR
dc.subjectIon-pairingpt_BR
dc.subjectSynergismpt_BR
dc.subjectAntitumor activitypt_BR
dc.subjectCardiotoxicitypt_BR
dc.subject.otherCâncerpt_BR
dc.subject.otherQuimioterápicospt_BR
dc.subject.otherCompostos químicospt_BR
dc.titleCo-delivery of doxorubicin, docosahexaenoic acid, and -tocopherol succinate by nanostructured lipid carriers has a synergistic effect to enhance antitumor activity and reduce toxicitypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332220310684pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2458-6021pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8703-4283pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5650-6743pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7641-6585pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2474-5536pt_BR
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