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http://hdl.handle.net/1843/51369| Type: | Artigo de Periódico |
| Title: | Oral angiotensin-(1-7) peptide modulates intestinal microbiota improving metabolic profile in obese mice |
| Authors: | Amanda Souto Machado Cláudia Regina Vieira Ulisses Alves Pereira Theles de Oliveira Costa João Marcus Oliveira Andrade Robson a s Dos Santos Sergio Henrique Sousa Santos Janaína Ribeiro Oliveira Deborah Farias Lelis Victor Hugo Dantas Guimarães Alfredo Maurício Batista de Paula André Luiz Sena Guimarães Igor Viana Brandi Bruna Mara Aparecida de Carvalho Mesquita Diego Vicente da Costa |
| Abstract: | Background: Obesity is a serious health problem that dysregulate Renin-Angiotensin System (RAS) and intestinal microbiota. Objective: The present study aimed to evaluate the Angiotensin-(1-7) [ANG-(1-7)] oral formulation effects on obese mice intestinal microbiota. Methods: Mice were divided into four groups: obese and non-obese treated with ANG-(1-7) and obese and non-obese without ANG-(1-7) during four weeks. Results: We observed a significant decrease in the fasting plasma glucose, total cholesterol, triglycerides, and Low-density lipoprotein levels and increased High-density lipoprotein in animals treated with ANG-(1-7). The histological analysis showed intestinal villi height reduction in mice treated with ANG-(1-7). Additionally, increased Bacteroidetes and decreased Firmicutes (increased Bacteroidetes/ Firmicutes ratio) and Enterobacter cloacae populations were observed in the High-Fat Diet + ANG-(1-7) group. Receptor toll-like 4 (TLR4) intestinal mRNA expression was reduced in the HFD+ANG-(1-7) group. Finally, the intestinal expression of the neutral amino acid transporter (B0AT1) was increased in animals treated with ANG-(1-7), indicating a possible mechanism associated with tryptophan uptake. Conclusion: The results of the present study suggest for the first time an interaction between oral ANG-(1-7) and intestinal microbiota modulation. |
| Subject: | Intestinos -- Microbiologia Endotoxina Metabolismo Sistema renina-angiotensina Intestino delgado |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | http://dx.doi.org/10.2174/0929866528666210816115645 |
| URI: | http://hdl.handle.net/1843/51369 |
| Issue Date: | 2021 |
| metadata.dc.url.externa: | https://www.eurekaselect.com/article/117376i |
| metadata.dc.relation.ispartof: | Protein and peptide letters |
| Appears in Collections: | Artigo de Periódico |
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