Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/51493| Type: | Artigo de Periódico |
| Title: | Development of a bone-targeted pH-sensitive liposomal formulation containing doxorubicin: physicochemical characterization, cytotoxicity and biodistribution evaluation in a mice model of bone metastasis |
| Authors: | Diêgo dos Santos Ferreira Peter Caravan Lucas Antônio Miranda Ferreira Ricardo José Alves Mônica Cristina de Oliveira Samilla Dornellas Faria Sávia Caldeira de Araújo Lopes Cláudia Salviano Teixeira Ângelo Malachias de Souza Rogério Magalhães Paniago José Dias de Souza Filho Bruno Luís de Jesus Pinto Oliveira Alexander Sávio Ramos Guimarães |
| Abstract: | Despite recent advances in cancer therapy, the treatment of bone tumors remains a major challenge. A possible underlying hypothesis, limitation, and unmet need may be the inability of therapeutics to penetrate into dense bone mineral, which can lead to poor efficacy and high toxicity, due to drug uptake in healthy organs. The development of nanostructured formulations with high affinity for bone could be an interesting approach to overcome these challenges. |
| Subject: | Câncer Lipossomos Ossos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICX - DEPARTAMENTO DE FÍSICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.2147/IJN.S109966 |
| URI: | http://hdl.handle.net/1843/51493 |
| Issue Date: | 2016 |
| metadata.dc.url.externa: | https://pubmed.ncbi.nlm.nih.gov/27563241/ |
| metadata.dc.relation.ispartof: | International Journal of Nanomedicine |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Development of a bone-targeted ph-sensitive liposomal formulation containing doxorubicin.pdf | 1.01 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.