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http://hdl.handle.net/1843/51540| Type: | Artigo de Periódico |
| Title: | Physical and biological effects of paclitaxel encapsulation on disteraroylphosphatidylethanolamine-polyethyleneglycol polymeric micelles |
| Authors: | Caroline Mari Ramos Oda Antonio Augusto Malfatti Gasperini Ângelo Malachias de Souza Gwenaelle Elza Nathalie Pound-Lana Vanessa Carla Furtado Mosqueira Renata Salgado Fernandes Mônica Cristina de Oliveira André Luís Branco de Barros Elaine Amaral Leite |
| Abstract: | Simple size observations of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethyleneglycol)-2000] (DSPE-mPEG2000) polymeric micelles (PM) with different compositions including or not paclitaxel (PTX) are unable to evidence changes on the nanocarrier structure. In such system a detailed characterization using highly sensitive techniques such as X-ray scattering and asymmetric flow field flow fractionation coupled to multi-angle laser light scattering and dynamic light scattering (AF4-MALS-DLS) is mandatory to observe effects that take place by the addition of PTX and/or more lipid-polymer at PM, leading to complex changes on the structure of micelles, as well as in their supramolecular organization. SAXS and AF4-MALS-DLS suggested that PM can be found in the medium separately and highly organized, forming clusters of PM in the latter case. SAXS fitted parameters showed that adding the drug does not change the average PM size since the increase in core radius is compensated by the decrease in shell radius. SAXS observations indicate that PEG conformation takes place, changing from brush to mushroom depending on the PM composition. These findings directly reflect in in vivo studies of blood clearance that showed a longer circulation time of blank PM when compared to PM containing PTX. |
| Subject: | Câncer |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICX - DEPARTAMENTO DE FÍSICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.colsurfb.2019.110760 |
| URI: | http://hdl.handle.net/1843/51540 |
| Issue Date: | 2020 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S092777651930904X |
| metadata.dc.relation.ispartof: | Colloids and Surfaces B: Biointerfaces |
| Appears in Collections: | Artigo de Periódico |
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