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http://hdl.handle.net/1843/51758| Type: | Artigo de Periódico |
| Title: | Treatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone |
| Authors: | Rummenigge Oliveira Silva Armando da Silva Cunha Júnior Bruna Lopes da Costa Flávia Rodrigues da Silva Carolina Nunes da Silva Mayara Rodrigues Brandão de Paiva Lays Fernanda Nunes Dourado Ângelo Malachias de Souza Adriano Antunes de Souza Araújo Paula Santos Nunes |
| Abstract: | Some recent studies have shown that pirfenidone (PFD) has favorable results in the healing process of the cornea. However, PFD in solution exhibits short half-life after topical application, and in this context, a liquid crystal nanoparticle system containing PFD (PFD-LCNPs) was developed. The nanoparticles were characterized by transmission electron microscopy, atomic force microscopy, small angle X-ray diffraction and polarized light microscopy. The PFD-LCNPs had particle size and zeta potential of 247.3 nm and −33.60 mV (stores at 4 °C), respectively, and 257.5 nm and −46.00 mV (stored at 25 °C), respectively. The pH of the formulation was 6.9 and the encapsulation efficiency was 35.9%. The in vitro release profiles indicated that PFD sustained release from PFD-LCNPs for up to 12 h. In vitro study of ocular irritation (HET-CAM test) concluded that components of the formulation are well tolerated for ocular administration. Corneal re-epithelialization time after chemical burning was significantly reduced in rabbits treated with PFD-loaded LCNPs when compared to the group treated with a vehicle. In addition, the anti-inflammatory action of pirfenidone was observed by reducing myeloperoxidase activity (MPO) and inflammatory cells in the histology of the tissues of animals treated with PFD-LCNPs. These findings indicated that the PFD-LCNPs might have the potential for effective ocular drug delivery. |
| Subject: | Queimaduras químicas Nanopartículas Córnea Cicatrização de feridas |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICX - DEPARTAMENTO DE FÍSICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.ijpharm.2019.118466 |
| URI: | http://hdl.handle.net/1843/51758 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S037851731930506X |
| metadata.dc.relation.ispartof: | International Journal of Pharmaceutics |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Treatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone.pdf | 4.48 MB | Adobe PDF | View/Open |
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