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Type: Artigo de Periódico
Title: Treatment for chemical burning using liquid crystalline nanoparticles as an ophthalmic delivery system for pirfenidone
Authors: Rummenigge Oliveira Silva
Armando da Silva Cunha Júnior
Bruna Lopes da Costa
Flávia Rodrigues da Silva
Carolina Nunes da Silva
Mayara Rodrigues Brandão de Paiva
Lays Fernanda Nunes Dourado
Ângelo Malachias de Souza
Adriano Antunes de Souza Araújo
Paula Santos Nunes
Abstract: Some recent studies have shown that pirfenidone (PFD) has favorable results in the healing process of the cornea. However, PFD in solution exhibits short half-life after topical application, and in this context, a liquid crystal nanoparticle system containing PFD (PFD-LCNPs) was developed. The nanoparticles were characterized by transmission electron microscopy, atomic force microscopy, small angle X-ray diffraction and polarized light microscopy. The PFD-LCNPs had particle size and zeta potential of 247.3 nm and −33.60 mV (stores at 4 °C), respectively, and 257.5 nm and −46.00 mV (stored at 25 °C), respectively. The pH of the formulation was 6.9 and the encapsulation efficiency was 35.9%. The in vitro release profiles indicated that PFD sustained release from PFD-LCNPs for up to 12 h. In vitro study of ocular irritation (HET-CAM test) concluded that components of the formulation are well tolerated for ocular administration. Corneal re-epithelialization time after chemical burning was significantly reduced in rabbits treated with PFD-loaded LCNPs when compared to the group treated with a vehicle. In addition, the anti-inflammatory action of pirfenidone was observed by reducing myeloperoxidase activity (MPO) and inflammatory cells in the histology of the tissues of animals treated with PFD-LCNPs. These findings indicated that the PFD-LCNPs might have the potential for effective ocular drug delivery.
Subject: Queimaduras químicas
Cicatrização de feridas
language: eng Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
Rights: Acesso Aberto
Issue Date: 2019
metadata.dc.relation.ispartof: International Journal of Pharmaceutics
Appears in Collections:Artigo de Periódico

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