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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/51858
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dc.creatorJaciara Neves Sousapt_BR
dc.creatorAndré Luiz Sena Guimarãespt_BR
dc.creatorSérgio Henrique Sousa Santospt_BR
dc.creatorValéria Mafrapt_BR
dc.creatorBarbhara Mota Marinhopt_BR
dc.creatorVictor Hugo Dantas Guimarãespt_BR
dc.creatorLuís Paulo Oliveirapt_BR
dc.creatorSidnei Tavares dos Reispt_BR
dc.creatorTheles Costapt_BR
dc.creatorClaudia Regina Vieirapt_BR
dc.creatorAlfredo Mauricio Batista de Paulapt_BR
dc.date.accessioned2023-04-12T15:39:29Z-
dc.date.available2023-04-12T15:39:29Z-
dc.date.issued2021-
dc.citation.volume1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage7pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.phyplu.2021.100130pt_BR
dc.identifier.issn2667-0313pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/51858-
dc.description.resumoBackground: Davilla elliptica A. St.-Hil, also known as “lixeirinha or sambaibinha” is a shrub belonging to the Dilleniaceae family that occurs naturally in the Brazilian savannah (Cerrado). Research studies have shown evidence of its gastroprotective effect, as well as its benefits as an anti-nociceptive, anti-inflammatory, and antioxidant. However, there are no studies testing the potential effects of D. elliptica on treating metabolic parameters and obesity. Purpose: The aim of the present study was to investigate D. elliptica effects on hepatic steatosis induced by a high-fat/high-sugar diet. Methods: Animal experimentation was performed using male Swiss mice divided into four groups: ST (standard control), HLHS (obese control), HLHS+EAF (ethyl-acetate fraction), and HLHS+PL (leaf powder). The groups were treated for four weeks with 0.26 mg/kg/body weight. Results: The main findings of the present study showed that D. elliptica reduced hepatic lipid deposition, body weight, triglycerides, and total cholesterol levels. Gene expression analysis showed that GPX4 and PPARγ mRNA were significantly suppressed in HLHS + EAF mice livers. Conclusion: The present study contributes to elucidating the D. elliptica metabolic role in decreasing GPX4 and PPARγ expression in the HLHS group.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICA - INSTITUTO DE CIÊNCIAS AGRÁRIASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPhytomedicine Plus-
dc.rightsAcesso Abertopt_BR
dc.subject.otherDileniaceapt_BR
dc.subject.otherObesidadept_BR
dc.subject.otherSavanaspt_BR
dc.subject.otherCerradospt_BR
dc.subject.otherDoenças induzidas pela nutriçãopt_BR
dc.titleOral treatment with Davilla Elliptica A. St,-Hil. leaves improves liver steatosis and lipid metabolism on a diet-induced obese mice modelpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2667031321001123pt_BR
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