Acute oral treatment with resveratrol and Lactococcus Lactis Subsp. Lactis decrease body weight and improve liver proinflammatory markers in C57BL/6 mice

Keila Lopes Mendes; Deborah de Farias Lelis; Daniela Fernanda de Freitas; Luiz Henrique da Silveira; Alfredo Maurício Batista de Paula; André Luiz Sena Guimarães; Janaína Ribeiro de Oliveira; Mariléia Chaves Andrade; Sérgio Avelino Mota Nobre; Sérgio Henrique Sousa Santos

Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/52788

Type:	Artigo de Periódico
Title:	Acute oral treatment with resveratrol and Lactococcus Lactis Subsp. Lactis decrease body weight and improve liver proinflammatory markers in C57BL/6 mice
Authors:	Keila Lopes Mendes Deborah de Farias Lelis Daniela Fernanda de Freitas Luiz Henrique da Silveira Alfredo Maurício Batista de Paula André Luiz Sena Guimarães Janaína Ribeiro de Oliveira Mariléia Chaves Andrade Sérgio Avelino Mota Nobre Sérgio Henrique Sousa Santos
Abstract:	The present study aimed to evaluate the effects of resveratrol, a nutraceutical polyphenol, and Lactococcus lactis (bacteria probiotic), on metabolic parameters and hepatic proinflammatory markers expression. C57BL/6 mice were divided into 4 groups: Standard (ST), Lactococcus lactis (LL), Resveratrol (RSV), and Lactococcus lactis plus resveratrol (LL + RSV). Lactococcus lactis and resveratrol were administered by orogastric gavage. Blood parameters were assessed (total cholesterol, triglycerides, ALT and AST). IL-6 mRNA expression was evaluated by Real-time PCR and TNF-α protein expression was assessed by immunohistochemistry. The main findings showed that resveratrol and Lactococcus lactis association decreased body weight, aspartate aminotransferase and total cholesterol levels. LL and LL + RSV decreased triglycerides levels and IL-6 and TNF-α expression. These results open a perspective of using resveratrol and Lactococcus lactis to improve metabolic parameters and Lactococcus lactis in preventing inflammation and the hepatic diseases development.
Subject:	Polifenóis Inflamação Fígado - Doenças
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICA - INSTITUTO DE CIÊNCIAS AGRÁRIAS
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	https://doi.org/10.1007/s11033-021-06190-7
URI:	http://hdl.handle.net/1843/52788
Issue Date:	14-Feb-2021
metadata.dc.url.externa:	https://link.springer.com/article/10.1007/s11033-021-06190-7
metadata.dc.relation.ispartof:	Molecular Biology Reports
Appears in Collections:	Artigo de Periódico

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