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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/54409
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dc.creatorMoacir Ferreira Júniorpt_BR
dc.creatorSérgio de Assis Batistapt_BR
dc.creatorRafael Calvão Barbutopt_BR
dc.creatorAdriana Dias Gomespt_BR
dc.creatorDulciene Maria Magalhães Queirozpt_BR
dc.creatorIvana Duval Araújopt_BR
dc.creatorMarcelo Vidigal Caliaript_BR
dc.date.accessioned2023-06-02T20:16:09Z-
dc.date.available2023-06-02T20:16:09Z-
dc.date.issued2016-02-23-
dc.citation.volume61pt_BR
dc.citation.issue2pt_BR
dc.citation.spage231pt_BR
dc.citation.epage236pt_BR
dc.identifier.doi10.1016/j.advms.2016.02.003pt_BR
dc.identifier.issn18961126pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/54409-
dc.description.resumoPurpose: Human infection by Helicobacter pylori is associated with an increase in the number of gastrin producing G cells and a concomitant decrease of somatostatin-producing D cells. However, to our knowledge, changes in G and D cell numbers in response to infection with H. pylori CagA-positive strains containing different number of EPIYA-C phosphorylation sites have not been analyzed to date. Therefore,the aim of this study was to perform a quantitative analysis of the number of G and D cells in Mongolian gerbils challenged with H. pylori strains with different numbers of EPIYA-C motifs.Materials and methods: Mongolian gerbils were inoculated with isogenic H. pylori strains containing one to three phosphorylation sites. Mucosal fragments were evaluated by morphometry and immunohistochemistry using primary polyclonal rabbit anti-gastrin and anti-somatostatin antibodies. Positive cells were counted using an image analyzer.Results: Forty-five days after infection, there was a decrease in the number of D cells and an increase inthe G/D cell ratio in the group with three EPIYA-C. Six months after infection, there was a progressive and significant increase in the number of G cells and in the G/D cell ratio, with a concomitant decrease in thenumber of D cells, especially in the three EPIYA-C group.Conclusions: CagA-positive H. pylori strains containing a large number of EPIYA-C phosphorylation sites induce a decrease in D cell number and an increase in G cell number and G/D ratio, which were correlated with the number of inflammatory cells of the lamina propria.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CIRURGIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAdvances in Medical Sciences-
dc.rightsAcesso Restritopt_BR
dc.subjectHelicobacter pyloript_BR
dc.subjectG cellspt_BR
dc.subjectCélulas Secretoras de Somatostatinapt_BR
dc.subjectCag Apt_BR
dc.subject.otherHelicobacter pyloript_BR
dc.subject.otherCélulas Secretoras de Gastrinapt_BR
dc.subject.otherCélulas Secretoras de Somatostatinapt_BR
dc.titleCaga-positive helicobacter pylori strain containing three epiya c phosphorylation sites produces increase of g cell and decrease of d cell in experimentally infected gerbils (meriones unguiculatus)pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1896112616000158?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6488-734Xpt_BR
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