1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/54520
Full metadata record
DC FieldValueLanguage
dc.creatorVinícius Rodrigues Tarantonunespt_BR
dc.creatorIvana Duval-araujopt_BR
dc.creatorPaula Vieira Teixeira Vidigalpt_BR
dc.creatorMárcio Tadeu Pereirapt_BR
dc.creatorLuís Carlos Duarte Ladeirapt_BR
dc.creatorMarcelo Vidigal Caliaript_BR
dc.creatorFabrício Marcus Silva Oliveirapt_BR
dc.creatorAina Liz Alves Cesarpt_BR
dc.creatorAndré Augusto Gomes Faracopt_BR
dc.creatorRafael Calvão Barbutopt_BR
dc.date.accessioned2023-06-05T19:22:19Z-
dc.date.available2023-06-05T19:22:19Z-
dc.date.issued2021-07-24-
dc.citation.volume36pt_BR
dc.citation.issue8pt_BR
dc.citation.spage1pt_BR
dc.citation.epage7pt_BR
dc.identifier.doi10.1590/acb360805pt_BR
dc.identifier.issn16782674pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/54520-
dc.description.resumoPurpose: The present study aimed at testing a new formulation of mesalazine linked to chondroitin sulfate and its components alone in the treatment of actinic proctitis in rats. Methods: Forty-seven female Wistar rats were submitted to pelvic radiation and divided into eight groups: control A, mesalazine A, chondroitin A, and conjugate A, gavage of the according substance two weeks after irradiation and sacrifice three weeks after oral treatment; control C, mesalazine C, chondroitin C, and conjugate C, sacrifice six weeks after oral treatment. The rectum was submitted to histological characterization for each of the findings: inflammatory infiltrate, epithelial degeneration, mucosal necrosis, and fibrosis. Results: The inflammatory infiltrate was more intense in chondroitin A, mesalazine A, and conjugate C. The collagen deposition was less intense in chondroitin A, and mesalazine A, and more intense in control C. Conclusion: Mesalazine and chondroitin alone were efficacious in inducing a delayed inflammatory response, hence reducing the late fibrosis. The conjugate was able to induce an ever more delayed inflammatory response.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofActa Cirúrgica Brasileira-
dc.rightsAcesso Abertopt_BR
dc.subjectRadiotherapypt_BR
dc.subjectProctitispt_BR
dc.subjectMesalaminept_BR
dc.subjectChondroitinpt_BR
dc.subjectInflammationpt_BR
dc.subjectRatspt_BR
dc.subject.otherRadioterapiapt_BR
dc.subject.otherProctitept_BR
dc.subject.otherMesalaminapt_BR
dc.subject.otherCondroitinapt_BR
dc.subject.otherInflamaçãopt_BR
dc.subject.otherRatospt_BR
dc.titleEvaluation of mesalazine polymeric conjugate in the treatment of actinic proctitis in ratspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/acb/a/Vfrcn7vM34HBV3MYrvZnJ7h/?lang=enpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6488-734Xpt_BR
Appears in Collections:Artigo de Periódico

Files in This Item:
File Description SizeFormat 
Evaluation of mesalazine polymeric conjugate in the treatment pdfa.pdf358.62 kBAdobe PDFView/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.