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Tipo:	Artigo de Periódico
Título:	Serum levels of vancomycin: is there a prediction using doses in mg/kg/day or m2/day for neonates?
Autor(es):	Roberta Maia de Castroromanelli Leni Márcia Anchieta Juliana Chaves Abreu Fernandes Mariana Antunes Faria Lima Taís Marina de Souza Viviane Rosado Wanessa Trindade Clemente Paulo Augusto Moreira Camargos
Resumen:	Coagulase-negative Staphylococcus has been identified as the main nosocomial agent of neonatal late-onset sepsis. However, based on the pharmacokinetics and erratic distribution of vancomycin, recommended empirical dose is not ideal, due to the inappropriate serum levels that have been measured in neonates. The aim of this study was to evaluate serum levels of vancomycin used in newborns and compare the prediction of adequate serum levels based on doses calculated according to mg/kg/day and m2/day. This is an observational reprospective cohort at a referral neonatal unit, from 2011 to 2013. Newborns treated with vancomycin for the first episode of late-onset sepsis were included. Total dose in mg/kg/day, dose/m2/day, age, weight, body surface and gestational age were identified as independent variables. For predictive analysis of adequate serum levels, multiple linear regressions were performed. The Receiver Operating Characteristic curve for proper serum vancomycin levels was also obtained. A total of 98 patients received 169 serum dosages of the drug, 41 (24.3%) of the doses had serum levels that were defined as appropriate. Doses prescribed in mg/kg/day and dose/m2/day predicted serum levels in only 9% and 4% of cases, respectively. Statistical significance was observed with higher doses when the serum levels were considered as appropriate (p < 0.001). A dose of 27 mg/kg/day had a sensitivity of 82.9% to achieve correct serum levels of vancomycin. Although vancomycin has erratic serum levels and empirical doses cannot properly predict the target levels, highest doses in mg/kg/day were associated with adequate serum levels
Asunto:	Vancomicina Cálculos da Dosagem de Medicamento Farmacocinética Lactente Recém-Nascido Sepse Neonatal
Idioma:	eng
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Institución:	UFMG
Departamento:	MED - DEPARTAMENTO DE PEDIATRIA MED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR
Tipo de acceso:	Acesso Aberto
Identificador DOI:	10.1016/j.bjid.2016.06.008
URI:	http://hdl.handle.net/1843/55647
Fecha del documento:	12-ago-2016
metadata.dc.url.externa:	https://www.scielo.br/j/bjid/a/nD6MvFqZ7JBSdVfxLYGX5Vv/?lang=en
metadata.dc.relation.ispartof:	Brazilian Journal of Infectious Diseases
Aparece en las colecciones:	Artigo de Periódico

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