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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55647
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dc.creatorRoberta Maia de Castroromanellipt_BR
dc.creatorLeni Márcia Anchietapt_BR
dc.creatorJuliana Chaves Abreu Fernandespt_BR
dc.creatorMariana Antunes Faria Limapt_BR
dc.creatorTaís Marina de Souzapt_BR
dc.creatorViviane Rosadopt_BR
dc.creatorWanessa Trindade Clementept_BR
dc.creatorPaulo Augusto Moreira Camargospt_BR
dc.date.accessioned2023-06-30T19:29:48Z-
dc.date.available2023-06-30T19:29:48Z-
dc.date.issued2016-08-12-
dc.citation.volume20pt_BR
dc.citation.spage451pt_BR
dc.citation.epage456pt_BR
dc.identifier.doi10.1016/j.bjid.2016.06.008pt_BR
dc.identifier.issn14138670pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55647-
dc.description.resumoCoagulase-negative Staphylococcus has been identified as the main nosocomial agent of neonatal late-onset sepsis. However, based on the pharmacokinetics and erratic distribution of vancomycin, recommended empirical dose is not ideal, due to the inappropriate serum levels that have been measured in neonates. The aim of this study was to evaluate serum levels of vancomycin used in newborns and compare the prediction of adequate serum levels based on doses calculated according to mg/kg/day and m2/day. This is an observational reprospective cohort at a referral neonatal unit, from 2011 to 2013. Newborns treated with vancomycin for the first episode of late-onset sepsis were included. Total dose in mg/kg/day, dose/m2/day, age, weight, body surface and gestational age were identified as independent variables. For predictive analysis of adequate serum levels, multiple linear regressions were performed. The Receiver Operating Characteristic curve for proper serum vancomycin levels was also obtained. A total of 98 patients received 169 serum dosages of the drug, 41 (24.3%) of the doses had serum levels that were defined as appropriate. Doses prescribed in mg/kg/day and dose/m2/day predicted serum levels in only 9% and 4% of cases, respectively. Statistical significance was observed with higher doses when the serum levels were considered as appropriate (p < 0.001). A dose of 27 mg/kg/day had a sensitivity of 82.9% to achieve correct serum levels of vancomycin. Although vancomycin has erratic serum levels and empirical doses cannot properly predict the target levels, highest doses in mg/kg/day were associated with adequate serum levelspt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBrazilian Journal of Infectious Diseases-
dc.rightsAcesso Abertopt_BR
dc.subjectVancomycinpt_BR
dc.subjectDrug dosage calculationspt_BR
dc.subjectPharmacokineticspt_BR
dc.subjectInfantpt_BR
dc.subjectNewbornpt_BR
dc.subjectSepsispt_BR
dc.subject.otherVancomicinapt_BR
dc.subject.otherCálculos da Dosagem de Medicamentopt_BR
dc.subject.otherFarmacocinéticapt_BR
dc.subject.otherLactentept_BR
dc.subject.otherRecém-Nascidopt_BR
dc.subject.otherSepse Neonatalpt_BR
dc.titleSerum levels of vancomycin: is there a prediction using doses in mg/kg/day or m2/day for neonates?pt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.scielo.br/j/bjid/a/nD6MvFqZ7JBSdVfxLYGX5Vv/?lang=enpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0848-3740pt_BR
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