Use este identificador para citar ou linkar para este item:
http://hdl.handle.net/1843/55648| Tipo: | Artigo de Periódico |
| Título: | Procalcitonin-guided protocol is not useful to manage antibiotic therapy in febrile neutropenia: a randomized controlled trial |
| Autor(es): | Stella Sala Soareslima Vandack Nobre Roberta Maia de Castro Romanelli Wanessa Trindade Clemente Henrique Neves da Silva Bittencourt Ana Catarina Mourão Melo Luciana Caetano Botelho Salomão José Carlos Serufo |
| Resumo: | Febrile neutropenia (FN) requires immediate use of antibiotics (ATB), and procalcitonin (PCT) is proven to be useful in guiding antibiotic therapy in different settings. This study investigated the use of PCT as a guide for the duration of ATB in FN. A randomized controlled trial was carried out from January–December 2010. A total of 62 hematological adult patients with FN were randomized, in 1:1 ratio, into two groups: (1) PCT group: length of ATB guided by institu tional protocol plus PCT dynamics, and (2) control group: duration of ATB in accordance with institutional protocol. There was no difference between groups regarding the use of ATB for the first episode of fever (HR 1.14, 95 % CI 0.66–1.95, p = 0.641), with equivalent median duration of ATB therapy (PCT group 9.0 days and control group 8.0 days, p = 0.67), and median number of days without ATB (0 days, IQR 0–2 days for both groups, p = 0.96). We observed no difference in clinical cure rate (p = 0.68), infection relapse (p = 1.0), superinfection (p = 0.85), length of hospitalization (p = 0.64), and mortality at 28 days (p= 0.39) and at 90 days (p = 0.72). Considering the cut-off of 0.5 ng/ml, PCT was cor related with bacteremia (sensitivity of 51.9 % and specificity of 76.5 %). In this randomized controlled trial, adding a PCT guided protocol to the standard recommendations did not reduce the use of antibiotics in febrile neutropenia, although no apparent harm was caused. PCT proved to be a marker of bacteremia in this setting. |
| Assunto: | Pró-Calcitonina Neutropenia Febril Antibacterianos Infecção Hospitalar |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | MED - DEPARTAMENTO DE PEDIATRIA MED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTAR |
| Tipo de Acesso: | Acesso Restrito |
| Identificador DOI: | 10.1007/s00277-016-2639-5 |
| URI: | http://hdl.handle.net/1843/55648 |
| Data do documento: | 27-Abr-2016 |
| metadata.dc.url.externa: | https://link.springer.com/article/10.1007/s00277-016-2639-5 |
| metadata.dc.relation.ispartof: | Annals of Hematology |
| Aparece nas coleções: | Artigo de Periódico |
Arquivos associados a este item:
Não existem arquivos associados a este item.
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.