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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/55648
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dc.creatorStella Sala Soareslimapt_BR
dc.creatorVandack Nobrept_BR
dc.creatorRoberta Maia de Castro Romanellipt_BR
dc.creatorWanessa Trindade Clementept_BR
dc.creatorHenrique Neves da Silva Bittencourtpt_BR
dc.creatorAna Catarina Mourão Melopt_BR
dc.creatorLuciana Caetano Botelho Salomãopt_BR
dc.creatorJosé Carlos Serufopt_BR
dc.date.accessioned2023-06-30T19:43:43Z-
dc.date.available2023-06-30T19:43:43Z-
dc.date.issued2016-04-27-
dc.citation.volume95pt_BR
dc.citation.issue7pt_BR
dc.citation.spage1169pt_BR
dc.citation.epage1176pt_BR
dc.identifier.doi10.1007/s00277-016-2639-5pt_BR
dc.identifier.issn09395555pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/55648-
dc.description.resumoFebrile neutropenia (FN) requires immediate use of antibiotics (ATB), and procalcitonin (PCT) is proven to be useful in guiding antibiotic therapy in different settings. This study investigated the use of PCT as a guide for the duration of ATB in FN. A randomized controlled trial was carried out from January–December 2010. A total of 62 hematological adult patients with FN were randomized, in 1:1 ratio, into two groups: (1) PCT group: length of ATB guided by institu tional protocol plus PCT dynamics, and (2) control group: duration of ATB in accordance with institutional protocol. There was no difference between groups regarding the use of ATB for the first episode of fever (HR 1.14, 95 % CI 0.66–1.95, p = 0.641), with equivalent median duration of ATB therapy (PCT group 9.0 days and control group 8.0 days, p = 0.67), and median number of days without ATB (0 days, IQR 0–2 days for both groups, p = 0.96). We observed no difference in clinical cure rate (p = 0.68), infection relapse (p = 1.0), superinfection (p = 0.85), length of hospitalization (p = 0.64), and mortality at 28 days (p= 0.39) and at 90 days (p = 0.72). Considering the cut-off of 0.5 ng/ml, PCT was cor related with bacteremia (sensitivity of 51.9 % and specificity of 76.5 %). In this randomized controlled trial, adding a PCT guided protocol to the standard recommendations did not reduce the use of antibiotics in febrile neutropenia, although no apparent harm was caused. PCT proved to be a marker of bacteremia in this setting.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE PROPEDÊUTICA COMPLEMENTARpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofAnnals of Hematology-
dc.rightsAcesso Restritopt_BR
dc.subjectProcalcitoninpt_BR
dc.subjectFebrile neutropeniapt_BR
dc.subjectAntibioticpt_BR
dc.subjectInfectionpt_BR
dc.subject.otherPró-Calcitoninapt_BR
dc.subject.otherNeutropenia Febrilpt_BR
dc.subject.otherAntibacterianospt_BR
dc.subject.otherInfecção Hospitalarpt_BR
dc.titleProcalcitonin-guided protocol is not useful to manage antibiotic therapy in febrile neutropenia: a randomized controlled trialpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://link.springer.com/article/10.1007/s00277-016-2639-5pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0848-3740pt_BR
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