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http://hdl.handle.net/1843/55703| Type: | Artigo de Periódico |
| Title: | Potential role of adult hippocampal neurogenesis in traumatic brain injury |
| Authors: | Lucas Alexandre Santos Marzano Fabyolla Lucia Macedo de Castro Caroline Amaral Machado João Luís Vieira Monteiro de Barros Thiago Macedo e Cordeiro Ana Cristina Simões e Silva Antonio Lucio Teixeira Aline Silva de Miranda |
| Abstract: | Traumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI’s long-term consequences being the search for novel therapeutic targets, a goal of highest scientific and clinical priority. Some studies evaluated the benefits of treatments aimed at improving neurogenesis in TBI. In this scenario, herein, we reviewed current pre-clinical studies that evaluated different approaches to improving neurogenesis after TBI while achieving better cognitive outcomes, which may consist in interesting approaches for future treatments. |
| Subject: | Cérebro - Ferimentos e lesões Neurologia do desenvolvimento Hipocampo (Cérebro) Terapêutica |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MORFOLOGIA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | http://dx.doi.org/10.2174/0929867328666210923143713 |
| URI: | http://hdl.handle.net/1843/55703 |
| Issue Date: | 2022 |
| metadata.dc.url.externa: | https://www.eurekaselect.com/article/118144 |
| metadata.dc.relation.ispartof: | Current Medicinal Chemistry |
| Appears in Collections: | Artigo de Periódico |
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