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Type:	Artigo de Periódico
Title:	Azitromycin for chronic eosihophilic rhinosinusitis with nasal polyp: a placebo-controlled trial
Authors:	Isamara Simas de Oliveira Alessandro Fernandes Guimarães Gabriela Rafael Arantes Pêgas Carla Jorge Machado Giovanni Dantas Cassali Paulo Crossara Flávio Barbosa Nunes Helena Maria Gonçalves Becker Roberto Eustáquio Santos Guimarães
Abstract:	Background: Chronic eosinophilic rhinosinusitis with nasal polyps (CRSwNP eosinophilic) is characterised by the formation of benign and bilateral nasal polyps. We aimed to compare the effectiveness of azithromycin as an immunomodulator with the use of a placebo in patients presenting with CRSwNP concomitant with asthma and aspirin intolerance after 3 months of treatment and at a 1-year follow-up.Methodology: We performed a randomised, double-blind, placebo-controlled trial. Patients received 500 mg azithromycin orally three times/week for 12 weeks. Improvement was evaluated by staging, the Sino-Nasal Outcome Test (SNOT-22), and nasal polyp biopsy. Data collected at pretreatment and 3 months posttreatment were compared. Quality of life was evaluated at the 1-year follow-up. Results: Twenty-seven and 21 patients were treated with azithromycin and a placebo, respectively. The medication was well tolerated overall. Twenty patients (74%) in the azithromycin group and three patients (14%) in the placebo group were not referred for surgery at the end of the 3-month treatment. Regarding subjective improvement, there was a median decrease only in the azithromycin group, and the between-group difference was significant. SNOT-22 improvement was maintained in the azithromycin group at the 1-year follow-up. Conclusions: Azithromycin could be considered a therapeutic option for patients presenting with CRSwNP concomitant with asthma and aspirin intolerance.
Subject:	Aspirina Azitromicina Endoscopia Eosinófilos Pólipos Nasais
language:	por
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - DEPARTAMENTO DE PATOLOGIA MED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL MED - DEPARTAMENTO DE OFTALMOLOGIA E OTORRINOLARINGOLOGIA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	10.4193/Rhin20.071
URI:	http://hdl.handle.net/1843/56040
Issue Date:	10-Jul-2020
metadata.dc.url.externa:	https://www.rhinologyjournal.com/Abstract.php?id=2662
metadata.dc.relation.ispartof:	Rhinology
Appears in Collections:	Artigo de Periódico

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