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http://hdl.handle.net/1843/56245| Tipo: | Artigo de Periódico |
| Título: | Crude extract of cyanobacterium Radiocystis fernandoi strain R28 induces anemia and oxidative stress in fish erythrocytes |
| Autor(es): | Marise Margareth Sakuragui Marisa Narciso Fernandes Marcelo Gustavo Paulino Naiara Elisabete da Silva e Souza Driele Tavares Ana Paula Terezan Emanuele Pesenti Alessandra Giani João Batista Fernandes Marta Margarete Cestari |
| Resumo: | The cyanobacterium Radiocystis fernandoi has been frequently identified in cyanobacterial blooms in Brazil. Recently, R. fernandoi strain R28, which produces microcystin (MC)-RR and MC-YR, was isolated from the Furnas reservoir, Minas Gerais, Brazil. The present study evaluated the hematological variables and erythrocyte antioxidant responses, lipid peroxidation (LPO), and genotoxicity in a neotropical fish (Hoplias malabaricus) after acute and subchronic exposure to a crude extract (CE) of R. fernandoi strain R28. Acute exposure (12 or 96 h) consisted of a single intraperitoneal (i.p.) CE injection, and subchronic exposure consisted of one i.p. CE injection every 72 h for 30 days. After acute exposure, fish exhibited macrocytic anemia (12 h post-injection) followed by normocytic anemia (96 h post-injection). The increased activity of superoxide dismutase, glutathione peroxidase, glutathione-S-transferase, and the glutathione level in the erythrocytes did not prevent oxidative stress, manifested as lipid peroxidation and elevated DNA damage after acute exposure. After subchronic exposure, the hematological variables recovered, and the absence of erythrocyte oxidative stress suggests possible modulation by other biological factors, including a possible decrease in MC uptake by the cells and/or increasing detoxification efficiency that precludes erythrocyte damage. |
| Assunto: | Enzimas Cianobacteria Hematologia |
| Idioma: | por |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICB - DEPARTAMENTO DE BOTÂNICA |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1016/j.toxicon.2019.08.002 |
| URI: | http://hdl.handle.net/1843/56245 |
| Data do documento: | 2019 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0041010119304258 |
| metadata.dc.relation.ispartof: | Toxicon |
| Aparece nas coleções: | Artigo de Periódico |
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| Crude extract of cyanobacterium Radiocystis fernandoi strain R28 induces anemia and oxidative stress in fish erythrocytes.pdf | 516.22 kB | Adobe PDF | Visualizar/Abrir |
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