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http://hdl.handle.net/1843/56277| Tipo: | Artigo de Periódico |
| Título: | Developmental exposure to the flame retardant mixture firemaster 550 compromises adult bone integrity in male but not female rats |
| Autor(es): | Soraia Macari Kylie D. Rock Mariana S. Santos Virgínia T. M. Lima Raphael Escorsim Szawka Jamal Moss Brian Horman Heather B. Patisaul |
| Resumen: | Flame retardants (FRs) are used in a variety of common items from furniture to carpet to electronics to reduce flammability and combustion, but the potential toxicity of these compounds is raising health concerns globally. Organophosphate FRs (OPFRs) are becoming more prevalent as older, brominated FRs are phased out, but the toxicity of these compounds, and the FR mixtures that contain them, is poorly understood. Work in a variety of in vitro model systems has suggested that FRs may induce metabolic reprogramming such that bone density is compromised at the expense of increasing adiposity. To address this hypothesis, the present studies maternally exposed Wistar rat dams orally across gestation and lactation to 1000 µg daily of the FR mixture Firemaster 550 (FM 550) which contains a mixture of brominated FRs and OPFRs. At six months of age, the offspring of both sexeswereexaminedforevidenceofcompromisedbonecomposition. Bonedensity,composition,and marrow were all significantly affected, but only in males. The fact that the phenotype was observed months after exposure suggests that FM 550 altered some fundamental aspect of mesenchymal stem cell reprogramming. The severity of the phenotype and the human-relevance of the dose employed, affirm this is an adverse outcome meriting further exploration. |
| Asunto: | Endocrinologia Tecido adiposo Sexo - Diferenças |
| Idioma: | por |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA |
| Tipo de acceso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.3390/ijms21072553 |
| URI: | http://hdl.handle.net/1843/56277 |
| Fecha del documento: | 2020 |
| metadata.dc.url.externa: | https://www.mdpi.com/1422-0067/21/7/2553 |
| metadata.dc.relation.ispartof: | International Journal of Molecular Sciences |
| Aparece en las colecciones: | Artigo de Periódico |
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| archivo | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Developmental Exposure to the Flame Retardant Mixture Firemaster 550 Compromises Adult Bone Integrity in Male but not Female Rats.pdf | 453.95 kB | Adobe PDF | Visualizar/Abrir |
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