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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56277
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dc.creatorSoraia Macaript_BR
dc.creatorKylie D. Rockpt_BR
dc.creatorMariana S. Santospt_BR
dc.creatorVirgínia T. M. Limapt_BR
dc.creatorRaphael Escorsim Szawkapt_BR
dc.creatorJamal Mosspt_BR
dc.creatorBrian Hormanpt_BR
dc.creatorHeather B. Patisaulpt_BR
dc.date.accessioned2023-07-14T20:10:47Z-
dc.date.available2023-07-14T20:10:47Z-
dc.date.issued2020-
dc.citation.volume21pt_BR
dc.citation.issue7pt_BR
dc.citation.spage1pt_BR
dc.citation.epage12pt_BR
dc.identifier.doihttps://doi.org/10.3390/ijms21072553pt_BR
dc.identifier.issn1422-0067pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56277-
dc.description.resumoFlame retardants (FRs) are used in a variety of common items from furniture to carpet to electronics to reduce flammability and combustion, but the potential toxicity of these compounds is raising health concerns globally. Organophosphate FRs (OPFRs) are becoming more prevalent as older, brominated FRs are phased out, but the toxicity of these compounds, and the FR mixtures that contain them, is poorly understood. Work in a variety of in vitro model systems has suggested that FRs may induce metabolic reprogramming such that bone density is compromised at the expense of increasing adiposity. To address this hypothesis, the present studies maternally exposed Wistar rat dams orally across gestation and lactation to 1000 µg daily of the FR mixture Firemaster 550 (FM 550) which contains a mixture of brominated FRs and OPFRs. At six months of age, the offspring of both sexeswereexaminedforevidenceofcompromisedbonecomposition. Bonedensity,composition,and marrow were all significantly affected, but only in males. The fact that the phenotype was observed months after exposure suggests that FM 550 altered some fundamental aspect of mesenchymal stem cell reprogramming. The severity of the phenotype and the human-relevance of the dose employed, affirm this is an adverse outcome meriting further exploration.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Molecular Sciencespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectObesogenpt_BR
dc.subjectEndocrine disrupting chemicalspt_BR
dc.subjectEndocrine disrupting chemicalspt_BR
dc.subjectAdiposept_BR
dc.subjectCortical bonept_BR
dc.subjectPPAR gammapt_BR
dc.subjectSex differencept_BR
dc.subject.otherEndocrinologiapt_BR
dc.subject.otherTecido adiposopt_BR
dc.subject.otherSexo - Diferençaspt_BR
dc.titleDevelopmental exposure to the flame retardant mixture firemaster 550 compromises adult bone integrity in male but not female ratspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/1422-0067/21/7/2553pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7643-6589pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2954-1110pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2639-3469pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7924-1610pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1278-2890pt_BR
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