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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56281
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dc.creatorGabriel Henrique Campolina Silvapt_BR
dc.creatorHipácia Werneck Gomespt_BR
dc.creatorBruna T. Mariapt_BR
dc.creatorMaria C. Baratapt_BR
dc.creatorMaría J. Torrespt_BR
dc.creatorHector Contreraspt_BR
dc.creatorGermán A.B. Mahechapt_BR
dc.creatorCleida Aparecida de Oliveirapt_BR
dc.date.accessioned2023-07-14T20:20:29Z-
dc.date.available2023-07-14T20:20:29Z-
dc.date.issued2020-
dc.citation.volume242pt_BR
dc.citation.issue1pt_BR
dc.citation.spage1pt_BR
dc.citation.epage13pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.lfs.2019.117149pt_BR
dc.identifier.issn1879-0631pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56281-
dc.description.resumoAims: The purpose of this study was to describe a suitable experimental model for studying aging-related prostate disorders including cancer. Materials and methods: 12-month old Wistarratswere keptincontrol conditions (n=12)or treated(n= 16)for 6 months with Silastic implants filled with testosterone (T) and estradiol (E2). After the experiment period (at 18 months of age), animals were euthanized and the prostate and other organs were harvested, dissected, weighed, and processed for morphological, ultrastructural and molecular analyses. Key findings: We demonstrated that male rats of Wistar strain nicely recapitulate the carcinogenesis process taking place in the aging prostate through the arising of benign, precancerous and malignant lesions, and above all yields a modest incidence of spontaneous PCa (~36%). Moreover, our results highlight that 100% incidence of PCa and precancerous lesions such as prostatic intraepithelial neoplasia and proliferative inflammatory atrophy were achieved in this ratstrain after T+ E2 treatment, without changing the broad spectrum of changes that naturally emerge in the prostate at advanced ages. Such enhancement of precancerous lesions and tumors was linked to a decreased expression of E-cadherin andβ-catenin in parallel with an increase in Vimentin and Ncadherin, hallmark modifications of epithelial-mesenchymal transition. Significance: Our findings provide solid evidence that aged Wistar rats may be an excellent model for studies regarding human prostate biology and related disorders including cancer.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofLife Sciencespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectProstate lesionspt_BR
dc.subjectAdenocarcinomapt_BR
dc.subjectAgingpt_BR
dc.subjectAndrogen: estrogen imbalancept_BR
dc.subjectWistar ratpt_BR
dc.subject.otherProstatapt_BR
dc.subject.otherAdenocarcinomapt_BR
dc.subject.otherEnvelhecimentopt_BR
dc.titleTargeting Wistar rat as a model for studying benign, premalignant and malignant lesions of the prostatept_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S002432051931077Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4473-3340pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5243-8272pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4012-2662pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2907-0945pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9610-7846pt_BR
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