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http://hdl.handle.net/1843/56282| Type: | Artigo de Periódico |
| Title: | Basal cells show increased expression of aromatase and estrogen receptor α in prostate epithelial lesions of male aging rats |
| Authors: | Mônica Morais Santos Hipácia Werneck Gomes Gabriel Henrique Campolina Silva Leticia C. Santos Germán A. B. Mahecha Rex Hess Cleida Aparecida de Oliveira |
| Abstract: | Besides androgens, estrogen signaling plays a key role in normal development and pathologies of the prostate. Irreversible synthesis of estrogens from androgens is catalyzed by aromatase. Interestingly, animals lacking aromatase do not develop cancer or prostatitis, whereas those with overexpression of aromatase and, consequently, high estrogen levels develop prostatitis and squamous metaplasia via estrogen receptor 1 (ERα). Even with this evidence, the aromatase expression in the prostate is controversial. Moreover, little is known about the occurrence of age-dependent variation of aromatase and its association with histopathological changes commonly found in advanced age, a knowledge gap that is addressed herein. For this purpose, the immunoexpression of aromatase was evaluated in the prostatic complex of young adult to senile Wistar rats. ERα was also investigated, to extend our understanding of estrogen responsiveness in the prostate. Moderate cytoplasmic immunoreactivity for aromatase was detected in the glandular epithelium. Eventually, some basal cells showed intense staining for aromatase. The expression pattern for aromatase appeared similar in the normal epithelium when young and senile rats were compared; this result was corroborated by Western blotting. Conversely, in senile rats, there was an increase in the frequency of basal cells intensely stained for aromatase, which appeared concentrated in areas of intraepithelial proliferation and prostatitis. These punctual areas also presented increased ERα positivity. Together, these findings suggest a plausible source for hormonal imbalance favoring estrogen production, which, by acting through ERα, may favor the development of prostatic lesions commonly found in advanced age. |
| Subject: | Prostata Envelhecimento |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE MORFOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1210/en.2017-00773 |
| URI: | http://hdl.handle.net/1843/56282 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://academic.oup.com/endo/article/159/2/723/4600203 |
| metadata.dc.relation.ispartof: | Endocrinology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Basal Cells Show Increased Expression of Aromatase and Estrogen Receptor a in Prostate Epithelial Lesions of Male Aging Rat.pdf | 14.3 MB | Adobe PDF | View/Open |
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