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Type:	Artigo de Periódico
Title:	Triggering different brain states using asynchronous serial communication to the rat amygdala
Authors:	Flávio Afonso Gonçalves Mourão André Luiz Vieira Lockmann Gabriel Perfeito Castro Daniel de Castro Medeiros Marina Pádua Reis Grace Schenatto Pereira Moraes André Ricardo Massensini Marcio Flávio Dutra Moraes
Abstract:	Inputting information to the brain through direct electrical microstimulation must consider how underlying neural networks encode information. One unexplored possibility is that a single electrode delivering temporally coded stimuli, mimicking an asynchronous serial communication port to the brain, can trigger the emergence of different brain states. This work used a discriminative fear-conditioning paradigm in rodents in which 2 temporally coded microstimulation patterns were targeted at the amygdaloid complex. Each stimulus was a binary-coded “word” made up of 10 ms bins, with 1's representing a single pulse stimulus: A-1001111001 and B-1110000111. During 3 consecutive retention tests (i.e., day-word: 1-B; 2-A, and 3-B), only binary-coded words previously paired with a foot-electroshock elicited proper aversive behavior. To determine the neural substrates recruited by the different stimulation patterns, c-Fos expression was evaluated 90 min after the last retention test. Animals conditioned to word-B, after stimulation with word-B, demonstrated increased hypothalamic c-Fos staining. Animals conditioned to word-A, however, showed increased prefrontal c-Fos labeling. In addition, prefrontal-cortex and hypothalamic c-Fos staining for, respectively, word-B- and word-A-conditioned animals, was not different than that of an unpaired control group. Our results suggest that, depending on the valence acquired from previous learning, temporally coded microstimulation activates distinct neural networks and associated behavior.
Subject:	Amigdalas Medo
language:	por
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1093/cercor/bhu313
URI:	http://hdl.handle.net/1843/56295
Issue Date:	2016
metadata.dc.url.externa:	https://academic.oup.com/cercor/article/26/5/1866/1753715?login=true
metadata.dc.relation.ispartof:	Cerebral Cortex
Appears in Collections:	Artigo de Periódico

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