Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56300
Type: Artigo de Evento
Title: N-Methyl-D-Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection
Authors: Vivian Vasconcelos Costa
Julia Maria S. Araújo
Allysson Cramer
Ana Luíza Campos Vila Real
Lucas Secchim Ribeiro
Silvia Ines Sardi
Anderson J. Ferreira
Fabiana Simão Machado
Antônio Costa de Oliveira
Antônio Lúcio Teixeira
Helder Nakaya
Danielle da Glória de Souza
Fabiola M. Ribeiro
Mauro Martins Teixeira
Rebeca de Paiva Froes Rocha
Flavia R. Silva
Juliana G. Doria
Isabella Guimarães Olmo
Rafael Elias Marques Pereira Silva
Celso Martins Queiroz Junior
Giselle Foureaux
Juliana Lemos Del Sarto
Abstract: Zika virus (ZIKV) infection is a global health emergency that causes significant neurodegeneration. Neurodegenerative processes may be exacerbated by N-methyl-D-aspartate receptor (NMDAR)-dependent neuronal excitoxicity. Here, we have exploited the hypothesis that ZIKV-induced neurodegeneration can be rescued by blocking NMDA overstimulation with memantine. Our results show that ZIKV actively replicates in primary neurons and that virus replication is directly associated with massive neuronal cell death. Interestingly, treatment with memantine or other NMDAR blockers, including dizocilpine (MK-801), agmatine sulfate, or ifenprodil, prevents neuronal death without interfering with the ability of ZIKV to replicate in these cells. Moreover, in vivo experiments demonstrate that therapeutic memantine treatment prevents the increase of intraocular pressure (IOP) induced by infection and massively reduces neurodegeneration and microgliosis in the brain of infected mice. Our results indicate that the blockade of NMDARs by memantine provides potent neuroprotective effects against ZIKV-induced neuronal damage, suggesting it could be a viable treatment for patients at risk for ZIKV infection-induced neurodegeneration.
Subject: Medicina
Microbiologia
Pressão intra-ocular
language: por
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: ICB - DEPARTAMENTO DE MORFOLOGIA
Rights: Acesso Aberto
metadata.dc.identifier.doi: https://doi.org/10.1128/mbio.00350-17
URI: http://hdl.handle.net/1843/56300
Issue Date: 2017
metadata.dc.url.externa: https://journals.asm.org/doi/10.1128/mBio.00350-17
metadata.dc.relation.ispartof: American Society for Microbiology
Appears in Collections:Artigo de Evento



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