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http://hdl.handle.net/1843/56301| Type: | Artigo de Periódico |
| Title: | Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil |
| Authors: | Tauyne Menegaldo Pinheiro Bárbara Aparecida Chaves Mayara Marques Carneiro da Silva Izabella Cristina Andrade Batista Michelle Premazzi Papa Lana Monteiro Meuren Carolina Gonçalves de Oliveira Lucas Flavio Lemos Matassoli Laura Helena Vega Gonzales Gil Adriana Bozzi Carlos Eduardo Calzavara Silva Mânlio Tasso de Oliveira Mota Luciana Barros de Arruda Danielle da Glória de Souza Mauro Martins Teixeira Nikos Vasilakis Maurício Lacerda Nogueira Aripuanã Sakurada Aranha Watanabe Joice Matos Biselli Périco Betânia Paiva Drumond Milene Rocha Ribeiro Danila Vedovello João Pessoa Araújo Paulo Filemon Paolucci Pimenta |
| Abstract: | The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In São José do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in São José do Rio Preto. |
| Subject: | Dengue - Epidemiologia São Jose do Rio Preto, Região de (SP) |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MICROBIOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1371/journal.pntd.0006525 |
| URI: | http://hdl.handle.net/1843/56301 |
| Issue Date: | 2018 |
| metadata.dc.url.externa: | https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006525 |
| metadata.dc.relation.ispartof: | PLOS Neglected Tropical Diseases |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil.pdf | 3.51 MB | Adobe PDF | View/Open |
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