Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56309
Type: Artigo de Periódico
Title: Soluble tumor necrosis factor receptors as predictors of 1-year mortality and renal dysfunction after liver transplantation
Authors: Bruno Salomemorais
Antonio Lucio Teixeira Junior
Jader Freitas Maciel
Angela Aparecida Lima
Izabela Guimaraes Barbosa
Marcelo Dias Sanches
Abstract: Background: Several risk factors influence survival after liver transplantation (LT). Some research has demonstrated a relationship between soluble tumor necrosis factor receptors (sTNFRs) and worse clinical liver disease outcomes, but there are no data showing an association between sTNFRs and outcomes after LT. The primary aim of this study was to determine whether an association exists between perioperative sTNFRs and renal dysfunction or mortality after LT. Methods: Data were collected prospectively from 122 patients submitted to deceased-donor orthotopic LT. Blood samples were collected at seven different perioperative times and analyzed by ELISA. The statistical analysis included univariate analysis followed by logistic regression. The predictive value of significant variables was assessed using ROC curves. Results: One-month and 1-year LT survivals were 91% and 81%, respectively. Increased levels of soluble tumor necrosis factor receptor 1 (sTNF-R1) after 24 h of graft perfusion were associated with postoperative Renal Replacement Therapy (RRT) (OR 1.25) and 1-year mortality (OR 1.1). RRT was associated with 30-day and 1-year LT mortality, with OR 19.78 and 45.45, respectively. Conclusion: A higher sTNF-R1 level measured 24 h after graft perfusion is an independent predictor of RRT and 1-year mortality after LT.
Subject: Citocinas
Transplante de Fígado
Mortalidade
Síndrome de Fanconi
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: MED - DEPARTAMENTO DE CIRURGIA
MED - DEPARTAMENTO DE CLÍNICA MÉDICA
MED - DEPARTAMENTO DE SAÚDE MENTAL
Rights: Acesso Restrito
metadata.dc.identifier.doi: https://doi.org/10.1016/j.trim.2016.01.006
URI: http://hdl.handle.net/1843/56309
Issue Date: 1-Feb-2016
metadata.dc.url.externa: https://www.sciencedirect.com/science/article/abs/pii/S0966327416300077?via%3Dihub
metadata.dc.relation.ispartof: Transplant Immunology
Appears in Collections:Artigo de Periódico

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