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http://hdl.handle.net/1843/56310| Type: | Artigo de Periódico |
| Title: | Peripheral levels of angiotensins are associated with depressive symptoms in parkinson's disease |
| Authors: | Natalia Pessoarocha Antonio Lucio Teixeira Junior Paula Luciana Scalzo Izabela Guimarães Barbosa Salvina Maria de Campos-carli Lívia Duarte Tavares Mariana Soares de Souza Paulo Pereira Christo Helton José Reis Ana Cristina Simões e Silva |
| Abstract: | Background: The pathogenesis of PD remains elusive. The renin-angiotensin-system (RAS) has recently been implicated in the degeneration of dopaminergic neurons. This study aimed to compare plasma levels of components of the RAS of individuals with PD with controls. We also investigated the association between these circulating markers and motor, depressive and cognitive parameters. Methods: Thirty PD patients and twenty controls were subjected to clinical evaluation, including cognitive and depressive symptoms assessment. Plasma levels of Angiotensin (Ang) I, Ang II, Ang- (1–7), angiotensin converting enzyme (ACE) and ACE2 were measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results: PD patients presented lower plasma levels of Ang I, Ang II and Ang- (1–7) than control individuals. Among PD patients, lower circulating levels of angiotensins were associated with increased severity of depressive symptoms. Conclusions: This is the first study showing that peripheral levels of RAS components are changed in PD and as sociated with depressive symptoms. |
| Subject: | Doença de Parkinson Sistema Renina-Angiotensina Depressão Cognição |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE PEDIATRIA MED - DEPARTAMENTO DE SAÚDE MENTAL |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.jns.2016.07.031 |
| URI: | http://hdl.handle.net/1843/56310 |
| Issue Date: | 14-Jul-2016 |
| metadata.dc.url.externa: | https://www.jns-journal.com/article/S0022-510X(16)30446-4/fulltext |
| metadata.dc.relation.ispartof: | Journal of the Neurological Sciences |
| Appears in Collections: | Artigo de Periódico |
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