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Type:	Artigo de Periódico
Title:	HTLV-1 Tax activates HIV-1 transcription in latency models
Authors:	Victor Emmanuel Viana Geddes Diego Pandeló José Fabio E. Leal Douglas F. Nixon Amilcar Tanuri Renato Santana de Aguiar
Abstract:	HIV-1 latency is a major obstacle to HIV-1 eradication. Coinfection with HTLV-1 has been associated with faster progression to AIDS. HTLV-1 encodes the transactivator Tax which can activate both HTLV-1 and HIV-1 transcription. Here, we demonstrate that Tax activates HIV transcription in latent CD4+ T cells. Tax promotes the activation of P-TEFb, releasing CDK9 and Cyclin T1 from inactive forms, promoting transcription elongation and reactivation of latent HIV-1. Tax mutants lacking interaction with the HIV-1-LTR promoter were not able to activate P-TEFb, with no subsequent activation of latent HIV. In HIV-infected primary resting CD4+ T cells, Tax-1 reactivated HIV-1 transcription up to five fold, confirming these findings in an ex vivo latency model. Finally, our results confirms that HTLV-1/Tax hijacks cellular partners, promoting HIV-1 transcription, and this interaction should be further investigated in HIV-1 latency studies in patients with HIV/ HTLV-1 co-infection.
Subject:	HIV (Virus) HTLV-I (Virus)
language:	por
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.1016/j.virol.2017.01.014
URI:	http://hdl.handle.net/1843/56337
Issue Date:	2017
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S0042682217300235?via%3Dihub
metadata.dc.relation.ispartof:	Virology
Appears in Collections:	Artigo de Periódico

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