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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56337
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dc.creatorVictor Emmanuel Viana Geddespt_BR
dc.creatorDiego Pandeló Josépt_BR
dc.creatorFabio E. Lealpt_BR
dc.creatorDouglas F. Nixonpt_BR
dc.creatorAmilcar Tanuript_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.date.accessioned2023-07-14T22:49:43Z-
dc.date.available2023-07-14T22:49:43Z-
dc.date.issued2017-
dc.citation.volume504pt_BR
dc.citation.spage45pt_BR
dc.citation.epage51pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.virol.2017.01.014pt_BR
dc.identifier.issn0042-6822pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56337-
dc.description.resumoHIV-1 latency is a major obstacle to HIV-1 eradication. Coinfection with HTLV-1 has been associated with faster progression to AIDS. HTLV-1 encodes the transactivator Tax which can activate both HTLV-1 and HIV-1 transcription. Here, we demonstrate that Tax activates HIV transcription in latent CD4+ T cells. Tax promotes the activation of P-TEFb, releasing CDK9 and Cyclin T1 from inactive forms, promoting transcription elongation and reactivation of latent HIV-1. Tax mutants lacking interaction with the HIV-1-LTR promoter were not able to activate P-TEFb, with no subsequent activation of latent HIV. In HIV-infected primary resting CD4+ T cells, Tax-1 reactivated HIV-1 transcription up to five fold, confirming these findings in an ex vivo latency model. Finally, our results confirms that HTLV-1/Tax hijacks cellular partners, promoting HIV-1 transcription, and this interaction should be further investigated in HIV-1 latency studies in patients with HIV/ HTLV-1 co-infection.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofVirologypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectHIV-1pt_BR
dc.subjectLatencypt_BR
dc.subjectHTLV-1pt_BR
dc.subjectTaxpt_BR
dc.subjectTaxpt_BR
dc.subjectResting cellspt_BR
dc.subject.otherHIV (Virus)pt_BR
dc.subject.otherHTLV-I (Virus)pt_BR
dc.titleHTLV-1 Tax activates HIV-1 transcription in latency modelspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0042682217300235?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0723-3873pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3243-5688pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2801-1786pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0570-750Xpt_BR
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