Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/56337
Type: | Artigo de Periódico |
Title: | HTLV-1 Tax activates HIV-1 transcription in latency models |
Authors: | Victor Emmanuel Viana Geddes Diego Pandeló José Fabio E. Leal Douglas F. Nixon Amilcar Tanuri Renato Santana de Aguiar |
Abstract: | HIV-1 latency is a major obstacle to HIV-1 eradication. Coinfection with HTLV-1 has been associated with faster progression to AIDS. HTLV-1 encodes the transactivator Tax which can activate both HTLV-1 and HIV-1 transcription. Here, we demonstrate that Tax activates HIV transcription in latent CD4+ T cells. Tax promotes the activation of P-TEFb, releasing CDK9 and Cyclin T1 from inactive forms, promoting transcription elongation and reactivation of latent HIV-1. Tax mutants lacking interaction with the HIV-1-LTR promoter were not able to activate P-TEFb, with no subsequent activation of latent HIV. In HIV-infected primary resting CD4+ T cells, Tax-1 reactivated HIV-1 transcription up to five fold, confirming these findings in an ex vivo latency model. Finally, our results confirms that HTLV-1/Tax hijacks cellular partners, promoting HIV-1 transcription, and this interaction should be further investigated in HIV-1 latency studies in patients with HIV/ HTLV-1 co-infection. |
Subject: | HIV (Virus) HTLV-I (Virus) |
language: | por |
metadata.dc.publisher.country: | Brasil |
Publisher: | Universidade Federal de Minas Gerais |
Publisher Initials: | UFMG |
metadata.dc.publisher.department: | ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS |
Rights: | Acesso Aberto |
metadata.dc.identifier.doi: | https://doi.org/10.1016/j.virol.2017.01.014 |
URI: | http://hdl.handle.net/1843/56337 |
Issue Date: | 2017 |
metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0042682217300235?via%3Dihub |
metadata.dc.relation.ispartof: | Virology |
Appears in Collections: | Artigo de Periódico |
Files in This Item:
File | Description | Size | Format | |
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HTLV-1 Tax activates HIV-1 transcription in latency models.pdf | 738.73 kB | Adobe PDF | View/Open |
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