Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/56341| Type: | Artigo de Periódico |
| Title: | Plasma levels of tumor necrosis factor superfamily molecules are increased in bipolar disorder |
| Authors: | Izabela Guimarães Barbosa Gabriela Neves Vaz Natalia Pessoa Rocha Rodrigo Machado-vieira Marcio Rogerio Diniz Ventura Rodrigo b. Huguet Moises e. Bauer Michael Berk Antônio l. Teixeira |
| Abstract: | Objective: Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD.Methods: Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the HamiltonDepression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA.Results: Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls. Conclusion: These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology. |
| Subject: | Transtorno Bipolar Receptor de TWEAK Receptores do Ligante Indutor de Apoptose Relacionado a TNF |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE SAÚDE MENTAL |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.9758/cpn.2017.15.3.269 |
| URI: | http://hdl.handle.net/1843/56341 |
| Issue Date: | 9-May-2017 |
| metadata.dc.url.externa: | https://www.cpn.or.kr/journal/view.html?doi=10.9758/cpn.2017.15.3.269 |
| metadata.dc.relation.ispartof: | Clinical Psychopharmacology and Neuroscience |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder pdfa.pdf | 488.85 kB | Adobe PDF | View/Open |
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