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http://hdl.handle.net/1843/56348| Type: | Artigo de Periódico |
| Title: | Zika virus disrupts molecular fingerprinting of human neurospheres |
| Authors: | Patricia P. Garcez Gabriela Vitória Patricia C. Sequeira Jaroslaw Sochacki Renato Santana de Aguiar Hellen Thais Fuzii Ana Maria Bispo de Filippis João Lídio da Silva Gonçalves Vianez Júnior Amilcar Tanuri Daniel Martins de Souza Stevens K. Rehen Juliana Minardi Nascimento Janaina Mota de Vasconcelos Rodrigo Madeiro da Costa Rodrigo Delvecchio Pablo Trindade Erick Correia Loiola Luiza M. Higa Juliana Silva Cassoli |
| Abstract: | Zika virus (ZIKV) has been associated with microcephaly and other brain abnormalities; however, the molecular consequences of ZIKV to human brain development are still not fully understood. Here we describe alterations in human neurospheres derived from induced pluripotent stem (iPS) cells infected with the strain of Zika virus that is circulating in Brazil. Combining proteomics and mRNA transcriptional profiling, over 500 proteins and genes associated with the Brazilian ZIKV infection were found to be differentially expressed. These genes and proteins provide an interactome map, which indicates that ZIKV controls the expression of RNA processing bodies, miRNA biogenesis and splicing factors required for self-replication. It also suggests that impairments in the molecular pathways underpinning cell cycle and neuronal differentiation are caused by ZIKV. These results point to biological mechanisms implicated in brain malformations, which are important to further the understanding of ZIKV infection and can be exploited as therapeutic potential targets to mitigate it. |
| Subject: | Vírus da Zika Microcefalia Feto - Cerebro - Anomalias |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | 10.1038/srep40780 (2017) |
| URI: | http://hdl.handle.net/1843/56348 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://www.nature.com/articles/srep40780#Sec3 |
| metadata.dc.relation.ispartof: | Scientific Reports |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Zika virus disrupts molecular fingerprinting of human neurospheres.pdf | 15.18 MB | Adobe PDF | View/Open |
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