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Tipo:	Artigo de Periódico
Título:	Epidemiological dynamics of SARS-CoV-2 VOC Gamma in Rio de Janeiro, Brazil
Autor(es):	Filipe Romero Rebello Moreira Marcelo Calado de Paula Tôrres Raíssa Mirella dos Santos Cunha da Costa Cássia Cristina Alves Gonçalves Débora Souza Faffe Rafael Mello Galliez Orlando da Costa Ferreira Junior Renato Santana de Aguiar André Felipe Andrade dos Santos Carolina Moreira Voloch Terezinha Marta Pereira Pinto Castiñeiras Mirela D'arc Amilcar Tanuri Diana Mariani Alice Laschuk Herlinger Francine Bittencourt Schiffler Átila Duque Rossi Isabela de Carvalho Leitão Thamiris dos Santos Miranda Matheus Augusto Calvano Cosentino
Resumen:	The emergence and widespread circulation of severe acute respiratory syndrome coronavirus 2 variants of concern (VOCs) or interest impose an enhanced threat to global public health. In Brazil, one of the countries most severely impacted throughout the pandemic, a complex dynamics involving variants co-circulation and turnover events has been recorded with the emergence and spread of VOC Gamma in Manaus in late 2020. In this context, we present a genomic epidemiology investigation based on samples collected between December 2020 and May 2021 in the second major Brazilian metropolis, Rio de Janeiro. By sequencing 244 novel genomes through all epidemiological weeks in this period, we were able to document the introduction and rapid dissemination of VOC Gamma in the city, driving the rise of the third local epidemic wave. Molecular clock analysis indicates that this variant has circulated locally since the first weeks of 2021 and only 7 weeks were necessary for it to achieve a frequency above 70per cent, consistent with rates of growth observedinManausandotherstates.Moreover,aBayesianphylogeographicreconstructionindicatesthatVOCGammaspreadthroughout Brazil between December 2020 and January 2021 and that it was introduced in Rio de Janeiro through at least 13 events coming from nearly all regions of the country. Comparative analysis of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) cycle threshold (Ct) values provides further evidence that VOC Gamma induces higher viral loads (N1 target; mean reduction of Ct: 2.7, 95percentconfidenceinterval=±0.7).Thisanalysiscorroboratesthepreviouslyproposedmechanisticbasisforthisvariant-enhanced transmissibility and distinguished epidemiological behavior. Our results document the evolution of VOC Gamma and provide independent assessment of scenarios previously studied in Manaus, therefore contributing to the better understanding of the epidemiological dynamics currently being surveyed in other Brazilian regions.
Asunto:	COVID-19 Brasil
Idioma:	por
País:	Brasil
Editor:	Universidade Federal de Minas Gerais
Sigla da Institución:	UFMG
Departamento:	ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS
Tipo de acceso:	Acesso Aberto
Identificador DOI:	https://doi.org/10.1093/ve/veab087
URI:	http://hdl.handle.net/1843/56354
Fecha del documento:	2021
metadata.dc.url.externa:	https://academic.oup.com/ve/article/7/2/veab087/6378621?login=true
metadata.dc.relation.ispartof:	Virus Evolution
Aparece en las colecciones:	Artigo de Periódico

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