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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56354
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dc.creatorFilipe Romero Rebello Moreirapt_BR
dc.creatorMarcelo Calado de Paula Tôrrespt_BR
dc.creatorRaíssa Mirella dos Santos Cunha da Costapt_BR
dc.creatorCássia Cristina Alves Gonçalvespt_BR
dc.creatorDébora Souza Faffept_BR
dc.creatorRafael Mello Galliezpt_BR
dc.creatorOrlando da Costa Ferreira Juniorpt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorAndré Felipe Andrade dos Santospt_BR
dc.creatorCarolina Moreira Volochpt_BR
dc.creatorTerezinha Marta Pereira Pinto Castiñeiraspt_BR
dc.creatorMirela D'arcpt_BR
dc.creatorAmilcar Tanuript_BR
dc.creatorDiana Marianipt_BR
dc.creatorAlice Laschuk Herlingerpt_BR
dc.creatorFrancine Bittencourt Schifflerpt_BR
dc.creatorÁtila Duque Rossipt_BR
dc.creatorIsabela de Carvalho Leitãopt_BR
dc.creatorThamiris dos Santos Mirandapt_BR
dc.creatorMatheus Augusto Calvano Cosentinopt_BR
dc.date.accessioned2023-07-15T00:17:12Z-
dc.date.available2023-07-15T00:17:12Z-
dc.date.issued2021-
dc.citation.volume7pt_BR
dc.citation.issue2pt_BR
dc.citation.spage1pt_BR
dc.citation.epage11pt_BR
dc.identifier.doihttps://doi.org/10.1093/ve/veab087pt_BR
dc.identifier.issn2057-1577pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56354-
dc.description.resumoThe emergence and widespread circulation of severe acute respiratory syndrome coronavirus 2 variants of concern (VOCs) or interest impose an enhanced threat to global public health. In Brazil, one of the countries most severely impacted throughout the pandemic, a complex dynamics involving variants co-circulation and turnover events has been recorded with the emergence and spread of VOC Gamma in Manaus in late 2020. In this context, we present a genomic epidemiology investigation based on samples collected between December 2020 and May 2021 in the second major Brazilian metropolis, Rio de Janeiro. By sequencing 244 novel genomes through all epidemiological weeks in this period, we were able to document the introduction and rapid dissemination of VOC Gamma in the city, driving the rise of the third local epidemic wave. Molecular clock analysis indicates that this variant has circulated locally since the first weeks of 2021 and only 7 weeks were necessary for it to achieve a frequency above 70per cent, consistent with rates of growth observedinManausandotherstates.Moreover,aBayesianphylogeographicreconstructionindicatesthatVOCGammaspreadthroughout Brazil between December 2020 and January 2021 and that it was introduced in Rio de Janeiro through at least 13 events coming from nearly all regions of the country. Comparative analysis of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) cycle threshold (Ct) values provides further evidence that VOC Gamma induces higher viral loads (N1 target; mean reduction of Ct: 2.7, 95percentconfidenceinterval=±0.7).Thisanalysiscorroboratesthepreviouslyproposedmechanisticbasisforthisvariant-enhanced transmissibility and distinguished epidemiological behavior. Our results document the evolution of VOC Gamma and provide independent assessment of scenarios previously studied in Manaus, therefore contributing to the better understanding of the epidemiological dynamics currently being surveyed in other Brazilian regions.pt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofVirus Evolutionpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectCOVID-19pt_BR
dc.subjectVariant of concern Gammapt_BR
dc.subjectLineage P.1pt_BR
dc.subjectRio de Janeiropt_BR
dc.subjectBrazilpt_BR
dc.subjectPhylodynamicspt_BR
dc.subjectPhylogeographypt_BR
dc.subject.otherCOVID-19pt_BR
dc.subject.otherBrasilpt_BR
dc.titleEpidemiological dynamics of SARS-CoV-2 VOC Gamma in Rio de Janeiro, Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://academic.oup.com/ve/article/7/2/veab087/6378621?login=truept_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7162-5070pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6587-3871pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2970-7889pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5255-5938pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0348-8374pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1970-8936pt_BR
dc.identifier.orcidhttps://orcid.org/0009-0001-0494-2631pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5182-4366pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4746-6049pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3644-0246pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1382-9988pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7660-7058pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6177-163Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6235-8807pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7919-612Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9372-6561pt_BR
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