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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/56376
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dc.creatorAline Farias Moreira da Silvapt_BR
dc.creatorCarlos Basílio Pinheiropt_BR
dc.creatorJackson Antonio Lamounier Camargos Resendept_BR
dc.creatorMauricio Lanznasterpt_BR
dc.date.accessioned2023-07-17T13:22:12Z-
dc.date.available2023-07-17T13:22:12Z-
dc.date.issued2017-
dc.citation.volume123pt_BR
dc.citation.spage132pt_BR
dc.citation.epage137pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.poly.2016.10.042pt_BR
dc.identifier.issn1873-3719pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/56376-
dc.description.resumoTwo new iron(III) complexes, [Fe(bhnq)(L1)]NO3·CH3OH·2H2O (1) and [Fe(bhnq)(L2)]ClO4·CH3OH (2) (L1 = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine and L2 = N,N′-dimethyl-N,N′-bis(pyridin-2-ylmethyl)ethylenediamine), were investigated as potential candidates for bioreductively activated prodrugs. These complexes present a distorted octahedral structure with 2,2′-bis(3-hydroxy-1,4-naphthoquinone), (bhnq)2−, coordinated in a bidentate fashion to the iron(III) ion. A reversible wave associated with the Fe3+/Fe2+couple was observed in MeCN for 1 and 2 respectively at −0.05 V and 0.01 V versus SHE. Unlike previously studied cobalt(III)-based analogs and one iron(III) platform that showed efficient bioreductive activation, complexes 1 and 2 undergo fast dissociation in aqueous buffered solutions with immediate release of the bhnq2− ligand. Therefore, we conclude that the labile 3d5 iron(III) ion is a limited bioreducible carrier for naphthoquinone-based prodrugs when coordinated to this [N2NPy2] platform. Considerable modification of the current ligands or the meticulous selection of other alternative ligand platforms may be necessary to attain this goal.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiropt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofPolyhedron-
dc.rightsAcesso Restritopt_BR
dc.subjectBioreductively activated prodrugspt_BR
dc.subjectProdrugs activated by hypoxiapt_BR
dc.subjectBioreducible carrierpt_BR
dc.subjectIronpt_BR
dc.subject.otherFerropt_BR
dc.subject.otherAnoxemiapt_BR
dc.titleEvaluation of Iron(iii)-N(amine)2N(py)2 complexes as potential bioreductively activated carriers for naphthoquinone-based drugspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0277538716305393pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6550-1517pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8674-1779pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5366-4156pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0477-0152pt_BR
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