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http://hdl.handle.net/1843/56376| Type: | Artigo de Periódico |
| Title: | Evaluation of Iron(iii)-N(amine)2N(py)2 complexes as potential bioreductively activated carriers for naphthoquinone-based drugs |
| Authors: | Aline Farias Moreira da Silva Carlos Basílio Pinheiro Jackson Antonio Lamounier Camargos Resende Mauricio Lanznaster |
| Abstract: | Two new iron(III) complexes, [Fe(bhnq)(L1)]NO3·CH3OH·2H2O (1) and [Fe(bhnq)(L2)]ClO4·CH3OH (2) (L1 = N,N′-bis(pyridin-2-ylmethyl)ethylenediamine and L2 = N,N′-dimethyl-N,N′-bis(pyridin-2-ylmethyl)ethylenediamine), were investigated as potential candidates for bioreductively activated prodrugs. These complexes present a distorted octahedral structure with 2,2′-bis(3-hydroxy-1,4-naphthoquinone), (bhnq)2−, coordinated in a bidentate fashion to the iron(III) ion. A reversible wave associated with the Fe3+/Fe2+couple was observed in MeCN for 1 and 2 respectively at −0.05 V and 0.01 V versus SHE. Unlike previously studied cobalt(III)-based analogs and one iron(III) platform that showed efficient bioreductive activation, complexes 1 and 2 undergo fast dissociation in aqueous buffered solutions with immediate release of the bhnq2− ligand. Therefore, we conclude that the labile 3d5 iron(III) ion is a limited bioreducible carrier for naphthoquinone-based prodrugs when coordinated to this [N2NPy2] platform. Considerable modification of the current ligands or the meticulous selection of other alternative ligand platforms may be necessary to attain this goal. |
| Subject: | Ferro Anoxemia |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE FÍSICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.poly.2016.10.042 |
| URI: | http://hdl.handle.net/1843/56376 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0277538716305393 |
| metadata.dc.relation.ispartof: | Polyhedron |
| Appears in Collections: | Artigo de Periódico |
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