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http://hdl.handle.net/1843/56434| Type: | Artigo de Periódico |
| Title: | Expression of EGFR family and p53 in a patient with Synchronous Primary Endometrial Adenocarcinoma and Clear Cell Renal Carcinoma: a case report |
| Other Titles: | Expressão da família EGFR e p53 em paciente com Adenocarcinoma Endometrial e Carcinoma Renal de Células Claras primários e sincrônicos: relato de caso |
| Authors: | Priscila Fernanda da Silva Martins Izabella Cristina Alves Souza Enio Ferreira Emerson Soares Veloso Tatiany Luiza Silveira Adam Underwood Fabiano Conde Araujo Helen Lima Del-Puerto |
| Abstract: | We present a case of a 69 year-old, non-obese, post-menopausal woman diagnosed with synchronous endometrial adenocarcinoma and renal cell carcinoma. Immunolocalization and expression of the EGFR, HER-2, HER-3, HER-4 and p53 proteins by immunohistochemistry (IHC) was performed to investigate synchronous expression of these proteins. The endometrial adenocarcinoma was a well-differentiated tumor, with discernable glandular structure with moderate mitotic index. IHC revealed weak HER-2, HER-3 and HER-4 staining of cell membranes in well-differentiated areas, and intense HER-2 and p53 staining in papillary areas. The renal cell carcinoma showed clear cell type, solid tumor, Fuhrman nuclear grade 2, presence of necrosis and hemorrhage. IHC revealed intense HER-2 and HER-4 staining of cell membranes, weak EGFR staining, and negative expression for HER3 and p53 protein. In summary, overexpression of HER-2 and HER-4 may correlate with histological grade of the tumor and patient prognosis. |
| Abstract: | Apresentamos um relato de caso de uma paciente com 69 anos, nao-obesa, pós-menopausa, diagnosticada com adenocarcinoma endometrial simultâneo ao carcinoma de células renais. A imunolocalizaçao e expressao das proteínas EGFR, HER-2, HER-3, HER-4 e p53 através de imunohistoquímica (IHC) foi realizada para investigar a simultaneidade na expressao dessas proteínas em ambos tumores. O adenocarcinoma endometrial era um tumor bem diferenciado, com estruturas grandulares discerníveis e com índice mitótico moderado. A IHC revelou fraca marcaçao das proteínas HER-2, HER-3 e HER-4 nas membranas celulares em áreas bem diferenciadas, e marcaçao intensa de HER-2 e p53 em áreas papilares. O carcinoma de células renais apresentou tipo células clara, tumor sólido, grau 2 de malignidade nuclear, presença de necrose e hemorragia. IHC revelou marcaçao intensa de HER-2 e HER-4 nas membranas celulares, fraca de EGFR e negativa para HER-3 e p53. Em resumo, a super expressao das proteínas HER-2 e HER-4 podem estar correlacionadas ao grau histológico dos tumores e ao prognóstico da paciente. |
| Subject: | Neoplasias do Endométrio Carcinoma de Células Renais Genes erbB-1 Genes p53 |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE PATOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.5935/2526-8732.20190011 |
| URI: | http://hdl.handle.net/1843/56434 |
| Issue Date: | 2019 |
| metadata.dc.url.externa: | http://www.brazilianjournalofoncology.com.br/details/65/en-US/expressao-da-familia-egfr-e-p53-em-paciente-com-adenocarcinoma-endometrial-e-carcinoma-renal-de-celulas-claras-primarios-e-sincronicos--relato-de-caso |
| metadata.dc.relation.ispartof: | Brazilian Journal of Oncology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Expression of EGFR family and p53 in a patient with Synchronous Primary Endometrial Adenocarcinoma and Clear Cell Renal Carcinoma_ a Case Report.pdf | 664.56 kB | Adobe PDF | View/Open |
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