Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/56493| Type: | Artigo de Periódico |
| Title: | Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes |
| Authors: | Átila Duque Rossi Renato Santana de Aguiar Luiza Mendonça Higa Alice Laschuk Herlinger Marcelo Ribeiro Alves Mariane Talon de Menezes Ana Lucia Moraes Giannini Cynthia Chester Cardoso Andrea da Poian Amilcar Tanuri |
| Abstract: | Dengue virus (DENV) is the most widespread arbovirus, responsible for a wide range of clinical manifestations, varying from self-limited illness to severe hemorrhagic fever. Dengue severity is associated with host intense proinflammatory response and monocytes have been considered one of the key cell types involved in the early steps of DENV infection and immunopathogenesis. To better understand cellular mechanisms involved in monocyte infection by DENV, we analyzed the expression levels of 754 human microRNAs in DENV-infected THP-1 cells, a human monocytic cell line. Eleven human microRNAs showed differential expression after DENV infection and gene ontology and enrichment analysis revealed biological processes potentially affected by these molecules. Five downregulated microRNAs were significantly linked to cellular response to stress, four to cell death/apoptosis, two to innate immune responses and one upregulated to vesicle mediated, TGF-β signaling, phosphatidylinositol mediated signaling, lipid metabolism process and blood coagulation. |
| Subject: | Dengue - Epidemiologia Relação hospedeiro-virus Monocitos Genetica - Expressão |
| language: | por |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.3389/fcimb.2021.714088 |
| URI: | http://hdl.handle.net/1843/56493 |
| Issue Date: | 2021 |
| metadata.dc.url.externa: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.714088/full |
| metadata.dc.relation.ispartof: | Frontiers in Cellular and Infection Microbiology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Differential Expression of Human MicroRNAs During Dengue Virus Infection in THP-1 Monocytes.pdf | 346.92 kB | Adobe PDF | View/Open |
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