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http://hdl.handle.net/1843/56498| Type: | Artigo de Periódico |
| Title: | Serum levels of interleukin-33 and its soluble form receptor (sst2) are associated with cognitive performance in patients with schizophrenia |
| Authors: | Salvina Mariade Campos-carli Antônio Lúcio Teixeira Aline Silva Miranda Ingrid Caroline Silva Dias Amanda de Oliveira Breno Fiuza Cruz Érica Leandro Marciano Vieira Natalia Pessoa Rocha Izabela Guimarães Barbosa João Vinícius Salgado |
| Abstract: | Objective: Changes in immune system have been reported in schizophrenia. This study aimed to evaluate the involvement of IL-33, a member of the IL-1 cytokine family, in schizophrenia and its association with cognitive performance in these patients.Methods: Forty patients with chronic schizophrenia and 40 healthy subjects participated in the study. Serum levels of IL-33 and sST2(soluble form of the IL-33 receptor) were measured using enzyme-linked immunosorbent assay (ELISA). Patients were evaluated with the Brief Assessment of Cognition in Schizophrenia (BACS) and the Schizophrenia Cognition Rating Scale (SCoRS). Results: Patients with schizophrenia and controls presented similar serum levels of IL-33 and sST2. Levels of both markers were positively correlated with cognitive performance in patients with schizophrenia. Conclusion: We found a significant correlation between IL-33 and sST2 levels and cognition in schizophrenia. Our results might help in the understanding of how immune markers are associated with cognitive impairment in schizophrenia. It remains to be determined whether the association between IL-33/sST2 and cognition is restricted to patients with schizophrenia. |
| Subject: | Esquizofrenia Interleucina-33 Testes Neuropsicológicos |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE SAÚDE MENTAL |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.comppsych.2017.01.008 |
| URI: | http://hdl.handle.net/1843/56498 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0010440X16304874?via%3Dihub |
| metadata.dc.relation.ispartof: | Comprehensive Psychiatry |
| Appears in Collections: | Artigo de Periódico |
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