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http://hdl.handle.net/1843/56514| Tipo: | Artigo de Periódico |
| Título: | The effect of insulin-induced hypoglycemia on inflammatory markers: a systematic review |
| Autor(es): | Juliana B.drummond Izabela Guimarães Barbosa Robert Dantzer Antonio l. Teixeira |
| Resumo: | Introduction: The effects of acute hypoglycemia on markers of inflammation have been investigated, but the results have been heterogeneous.Objective: We aimed to perform a systematic review about the acute effects of insulin-induced hypoglycemia on inflammatory markers in patients with diabetes as well as non-diabetic subjects.Methods: A systematic search of the literature using the electronic databases MEDLINE and SCOPUS was con ducted through September 2017. Search terms included: “hypoglycemia”,“ insulin”, “cytokines”, and “inflammation”. We included original studies assessing peripheral inflammatory markers during insulin-induced hypoglycemia in humans.Results: Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. Acute hypoglycemia increases total leukocyte number and several pro-inflammatory markers.Elevation in pro-inflammatory markers in response to insulin-induced acute hypoglycemia appears to be of similar magnitude in non-diabetic subjects and in type-1 diabetic patients with intact awareness of hypogly cemia. Adrenaline rises in response to acute hypoglycemia correlates with the increase of pro-inflammatory markers. Conclusion: Acute hypoglycemia induces a pro-inflammatory state in both type-1 diabetic and non-diabetic subjects with no apparent significant difference between these two populations. Activation of the sympathetic nervous system is a likely mediator of these effects. |
| Assunto: | Hipoglicemia Insulisina |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | MED - DEPARTAMENTO DE CLÍNICA MÉDICA MED - DEPARTAMENTO DE SAÚDE MENTAL |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1016/j.bbi.2018.05.003 |
| URI: | http://hdl.handle.net/1843/56514 |
| Data do documento: | 4-Mai-2018 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0889159118301740?via%3Dihub |
| metadata.dc.relation.ispartof: | Brain, Behavior, and Immunity |
| Aparece nas coleções: | Artigo de Periódico |
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| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| The effect of insulin-induced hypoglycemia on inflammatory markers pdfa.pdf | 412.15 kB | Adobe PDF | Visualizar/Abrir |
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